Peripheral Synucleinopathy in Early Parkinson's Disease: Submandibular Gland Needle Biopsy Findings

Charles Howard Adler, Brittany N. Dugger, Joseph G. Hentz, Michael L. Hinni, David G Lott, Erika M Driver-Dunckley, Shyamal Mehta, Geidy Serrano, Lucia I. Sue, Amy Duffy, Anthony Intorcia, Jessica Filon, Joel Pullen, Douglas G. Walker, Thomas G. Beach

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Introduction: Finding a peripheral tissue biopsy site to diagnose early PD would be of value for clinical care, biomarker validation, and as research enrollment criteria. Whereas autopsy and advanced PD studies suggest that the submandibular gland is an important biopsy site, there are no studies in early PD. The aim of this study was to determine whether needle biopsy of the submandibular gland reveals Lewy type alpha-synucleinopathy in early PD. Methods: Twenty-five early PD (duration

Original languageEnglish (US)
JournalMovement Disorders
DOIs
StateAccepted/In press - 2016

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Keywords

  • Biopsy
  • Parkinson's disease
  • Submandibular gland
  • Synuclein

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Adler, C. H., Dugger, B. N., Hentz, J. G., Hinni, M. L., Lott, D. G., Driver-Dunckley, E. M., Mehta, S., Serrano, G., Sue, L. I., Duffy, A., Intorcia, A., Filon, J., Pullen, J., Walker, D. G., & Beach, T. G. (Accepted/In press). Peripheral Synucleinopathy in Early Parkinson's Disease: Submandibular Gland Needle Biopsy Findings. Movement Disorders. https://doi.org/10.1002/mds.26476