Peripheral sensory abnormalities in patients with multiple sclerosis

Jeremy M. Shefner, Jonathan L. Carter, Christian Krarup

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Although multiple sclerosis primarily affects myelin within the central nervous system, both pathologic and physiological studies suggest that mild deficits in peripheral nervous system myelin may be common. To evaluate this question further, we performed near nerve studies on sural nerves of 14 patients with multiple sclerosis. Peak‐to‐peak amplitude and maximum conduction velocity were normal in 9 of 14 patients, while minimum conduction velocity, or the velocity of the slowest‐conducting component of the sensory action potential, was abnormally reduced in 9 patients. In addition, the supernormal period was evaluated for patients and compared with a control sample; multiple sclerosis patients showed a significant reduction in the amplitude of supernormality. Both the reduction in minimum conduction velocity and the alteration in the supernormal period are consistent with a mild defect in peripheral myelin.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalMuscle & Nerve
Volume15
Issue number1
DOIs
StatePublished - Jan 1992

Keywords

  • multiple sclerosis
  • neuropathy
  • sensory action potential

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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