Peripheral sensorimotor and autonomic neuropathy associated with systemic lupus erythematosus

Clinical, pathological and immunological features

P. A. Mccombe, J. G. Mcleod, J. D. Pollard, Y. P. Guo, T. J. Ingall

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The clinical features and pathological findings in the sural nerves are described of 7 patients with peripheral neuropathy; in 4 cases the criteria for diagnosis of systemic lupus erythematosus (SLE) were satisfied and in 3 other cases there was serological evidence of an undifferentiated connective tissue disease, most probably SLE. The peripheral neuropathy was of a chronic sensorimotor type with predominantly sensory features and gradual onset. In 2 cases the presentation was asymmetric. One patient had autonomic dysfunction. The pathological findings in the biopsied sural nerves were those of axonal degeneration and vasculitis. In 6 nerves there was increased expression of Class II (Ia) antigen within the nerve fascicle, perineurium and within endothelial cells.

Original languageEnglish (US)
Pages (from-to)533-549
Number of pages17
JournalBrain
Volume110
Issue number2
DOIs
StatePublished - Apr 1987
Externally publishedYes

Fingerprint

lupus erythematosus
Sural Nerve
peripheral nervous system diseases
Histocompatibility Antigens Class II
Endothelial cells
Peripheral Nervous System Diseases
Antigens
Nerve
Systemic Lupus Erythematosus
nerve tissue
Tissue
Connective Tissue Diseases
Vasculitis
Peripheral Nerves
Endothelial Cells
vasculitis
peripheral nerves
Degeneration
connective tissues
endothelial cells

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Peripheral sensorimotor and autonomic neuropathy associated with systemic lupus erythematosus : Clinical, pathological and immunological features. / Mccombe, P. A.; Mcleod, J. G.; Pollard, J. D.; Guo, Y. P.; Ingall, T. J.

In: Brain, Vol. 110, No. 2, 04.1987, p. 533-549.

Research output: Contribution to journalArticle

Mccombe, P. A. ; Mcleod, J. G. ; Pollard, J. D. ; Guo, Y. P. ; Ingall, T. J. / Peripheral sensorimotor and autonomic neuropathy associated with systemic lupus erythematosus : Clinical, pathological and immunological features. In: Brain. 1987 ; Vol. 110, No. 2. pp. 533-549.
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