Peripheral sensorimotor and autonomic neuropathy associated with systemic lupus erythematosus: Clinical, pathological and immunological features

P. A. Mccombe, J. G. Mcleod, J. D. Pollard, Y. P. Guo, T. J. Ingall

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

The clinical features and pathological findings in the sural nerves are described of 7 patients with peripheral neuropathy; in 4 cases the criteria for diagnosis of systemic lupus erythematosus (SLE) were satisfied and in 3 other cases there was serological evidence of an undifferentiated connective tissue disease, most probably SLE. The peripheral neuropathy was of a chronic sensorimotor type with predominantly sensory features and gradual onset. In 2 cases the presentation was asymmetric. One patient had autonomic dysfunction. The pathological findings in the biopsied sural nerves were those of axonal degeneration and vasculitis. In 6 nerves there was increased expression of Class II (Ia) antigen within the nerve fascicle, perineurium and within endothelial cells.

Original languageEnglish (US)
Pages (from-to)533-549
Number of pages17
JournalBrain
Volume110
Issue number2
DOIs
StatePublished - Apr 1 1987

ASJC Scopus subject areas

  • Clinical Neurology

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