Abstract
The clinical features and pathological findings in the sural nerves are described of 7 patients with peripheral neuropathy; in 4 cases the criteria for diagnosis of systemic lupus erythematosus (SLE) were satisfied and in 3 other cases there was serological evidence of an undifferentiated connective tissue disease, most probably SLE. The peripheral neuropathy was of a chronic sensorimotor type with predominantly sensory features and gradual onset. In 2 cases the presentation was asymmetric. One patient had autonomic dysfunction. The pathological findings in the biopsied sural nerves were those of axonal degeneration and vasculitis. In 6 nerves there was increased expression of Class II (Ia) antigen within the nerve fascicle, perineurium and within endothelial cells.
Original language | English (US) |
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Pages (from-to) | 533-549 |
Number of pages | 17 |
Journal | Brain |
Volume | 110 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1987 |
ASJC Scopus subject areas
- Clinical Neurology