Peripheral neuropathy in acromegaly

Phillip Anson Low, J. G. McLeod, J. R. Turtle, P. Donnelly, R. G. Wright

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Eleven patients with established acromegaly were investigated clinically and nerve conduction studies were performed on all subjects. A peripheral neuropathy was demonstrated in 8 patients. Sural nerve biopsy was performed in 4 subjects. There was an increase in fascicular size and a reduction in the density of myelinated and unmyelinated fibers. Subperineurial and endoneurial tissue was increased. Segmental demyelination was evident in teased single nerve fiber preparations, and small onion bulb formations were visible on electron microscopy. Peripheral neuropathy appears to be a frequent complication of acromegaly, and it may occur independently of the presence of diabetes.

Original languageEnglish (US)
Pages (from-to)139-152
Number of pages14
JournalBrain
Volume97
Issue number1
StatePublished - 1974
Externally publishedYes

Fingerprint

Acromegaly
peripheral nervous system diseases
Peripheral Nervous System Diseases
Nerve
nerve tissue
Sural Nerve
Onions
Fibers
Biopsy
Neural Conduction
nerve fibers
Demyelinating Diseases
Medical problems
Nerve Fibers
Fiber
onions
bulbs
Electron microscopy
diabetes
Onion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Low, P. A., McLeod, J. G., Turtle, J. R., Donnelly, P., & Wright, R. G. (1974). Peripheral neuropathy in acromegaly. Brain, 97(1), 139-152.

Peripheral neuropathy in acromegaly. / Low, Phillip Anson; McLeod, J. G.; Turtle, J. R.; Donnelly, P.; Wright, R. G.

In: Brain, Vol. 97, No. 1, 1974, p. 139-152.

Research output: Contribution to journalArticle

Low, PA, McLeod, JG, Turtle, JR, Donnelly, P & Wright, RG 1974, 'Peripheral neuropathy in acromegaly', Brain, vol. 97, no. 1, pp. 139-152.
Low PA, McLeod JG, Turtle JR, Donnelly P, Wright RG. Peripheral neuropathy in acromegaly. Brain. 1974;97(1):139-152.
Low, Phillip Anson ; McLeod, J. G. ; Turtle, J. R. ; Donnelly, P. ; Wright, R. G. / Peripheral neuropathy in acromegaly. In: Brain. 1974 ; Vol. 97, No. 1. pp. 139-152.
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