Peripheral nerve hemangioblastoma

C. Giannini, B. W. Scheithauer, L. C. Hellbusch, A. G. Rasmussen, M. W. Fox, S. R. McCormick, D. H. Davis

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Capillary hemangioblastoma (HB) is a benign, highly vascular tumor limited almost exclusively to the central nervous system (CNS). It occurs primarily in the posterior fossa and less often in the spinal cord. We report three cases of HB occurring in peripheral nerve, two intradural tumors arising in a C4 and a cauda equina nerve root, respectively, and a third lesion in the sciatic nerve at mid thigh. The patients, 1 woman and 2 men, ranged in age from 25 to 40 years. Two had yon Hippel-Lindau disease, an association usually found in one-third of CNS HBs, and one had a family history of pheochromocytoma. In every way, HBs of peripheral nerve were indistinguishable from their CNS counterpart. Ranging in size from 1.5 to 5.5 cm in diameter, the tumors were well circumscribed and contained a myriad of small caliber vessels lined by endothelial cells and surrounded by pericytes. Throughout, the lesions were rich in large, often vacuolated stromal cells. In all of the cases, these stained strongly for vimentin and neuron-specific enolase; only one showed focal S100 protein reactivity. Surgical therapy required excision of the affected nerve roots in the first two cases. In the third case, prominent extension of the tumor within epineurium permitted a microsurgical resection with sparing of sciatic nerve fascicles. No tumor recurred during a follow-up period of 5 to 20 months.

Original languageEnglish (US)
Pages (from-to)999-1004
Number of pages6
JournalModern Pathology
Volume11
Issue number10
StatePublished - Oct 1 1998

Keywords

  • Hemangioblastoma
  • Peripheral nerve
  • Von Hippel Lindau disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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