Peripheral mechanisms in the control of appetite and related experimental therapies in obesity

Michael Camilleri

doi:10.1016/j.regpep.2009.04.011

Peripheral mechanisms in the control of appetite and related experimental therapies in obesity

Michael Camilleri

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

The function of the stomach and the gut hormonal responses to food ingestion constitute highly integrated homeostatic responses that maintain euglycemia and normal digestion. This intrinsic feedback involves vagal and hormonal mechanisms. Important signals such as GLP-1 and PYY that arise peripherally induce satiation and also delay gastric emptying or increase insulin secretion. Novel therapies are being developed to mimic or enhance these feedback mechanisms and to control appetite as a means to treat obesity.

Original language	English (US)
Pages (from-to)	24-27
Number of pages	4
Journal	Regulatory Peptides
Volume	156
Issue number	1-3
DOIs	https://doi.org/10.1016/j.regpep.2009.04.011
State	Published - Aug 7 2009

Keywords

GLP-1
Incretin
PYY
Satiation
Satiety
Stomach

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Clinical Biochemistry
Cellular and Molecular Neuroscience

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10.1016/j.regpep.2009.04.011

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abstract = "The function of the stomach and the gut hormonal responses to food ingestion constitute highly integrated homeostatic responses that maintain euglycemia and normal digestion. This intrinsic feedback involves vagal and hormonal mechanisms. Important signals such as GLP-1 and PYY that arise peripherally induce satiation and also delay gastric emptying or increase insulin secretion. Novel therapies are being developed to mimic or enhance these feedback mechanisms and to control appetite as a means to treat obesity.",

keywords = "GLP-1, Incretin, PYY, Satiation, Satiety, Stomach",

author = "Michael Camilleri",

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Y1 - 2009/8/7

N2 - The function of the stomach and the gut hormonal responses to food ingestion constitute highly integrated homeostatic responses that maintain euglycemia and normal digestion. This intrinsic feedback involves vagal and hormonal mechanisms. Important signals such as GLP-1 and PYY that arise peripherally induce satiation and also delay gastric emptying or increase insulin secretion. Novel therapies are being developed to mimic or enhance these feedback mechanisms and to control appetite as a means to treat obesity.

AB - The function of the stomach and the gut hormonal responses to food ingestion constitute highly integrated homeostatic responses that maintain euglycemia and normal digestion. This intrinsic feedback involves vagal and hormonal mechanisms. Important signals such as GLP-1 and PYY that arise peripherally induce satiation and also delay gastric emptying or increase insulin secretion. Novel therapies are being developed to mimic or enhance these feedback mechanisms and to control appetite as a means to treat obesity.

KW - GLP-1

KW - Incretin

KW - PYY

KW - Satiation

KW - Satiety

KW - Stomach

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Peripheral mechanisms in the control of appetite and related experimental therapies in obesity

Abstract

Keywords

ASJC Scopus subject areas

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