Peripheral mechanisms in the control of appetite and related experimental therapies in obesity

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The function of the stomach and the gut hormonal responses to food ingestion constitute highly integrated homeostatic responses that maintain euglycemia and normal digestion. This intrinsic feedback involves vagal and hormonal mechanisms. Important signals such as GLP-1 and PYY that arise peripherally induce satiation and also delay gastric emptying or increase insulin secretion. Novel therapies are being developed to mimic or enhance these feedback mechanisms and to control appetite as a means to treat obesity.

Original languageEnglish (US)
Pages (from-to)24-27
Number of pages4
JournalRegulatory Peptides
Volume156
Issue number1-3
DOIs
StatePublished - Aug 7 2009

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Keywords

  • GLP-1
  • Incretin
  • PYY
  • Satiation
  • Satiety
  • Stomach

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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