Peripheral blood progenitor cell mobilization for autologous and allogeneic hematopoietic cell transplantation: Guidelines from the american society for blood and marrow transplantation

Hien K. Duong, Bipin N. Savani, Ed Copelan, Steven Devine, Luciano J. Costa, John R. Wingard, Paul Shaughnessy, Navneet Majhail, Miguel Angel Perales, Corey S. Cutler, William Bensinger, Mark R. Litzow, Mohamad Mohty, Richard E. Champlin, Helen Leather, Sergio Giralt, Paul A. Carpenter

Research output: Contribution to journalReview articlepeer-review

99 Scopus citations

Abstract

Peripheral blood progenitor cell mobilization practices vary significantly among institutions. Effective mobilization regimens include growth factor alone, chemotherapy and growth factor combined, and, more recently, incorporation of plerixafor with either approach. Many institutions have developed algorithms to improve stem cell mobilization success rates and cost-effectiveness. However, an optimal stem cell mobilization regimen has not been defined. Practical guidelines are needed to address important clinical questions, including which growth factor is optimal, what chemotherapy and dose is most effective, and when to initiate leukapheresis. We present recommendations, based on a comprehensive review of the literature, from the American Society of Blood and Marrow Transplantation.

Original languageEnglish (US)
Pages (from-to)1262-1273
Number of pages12
JournalBiology of Blood and Marrow Transplantation
Volume20
Issue number9
DOIs
StatePublished - Sep 2014

Keywords

  • Hematopoietic transplantation
  • Peripheral blood
  • Progenitor cell mobilization

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Peripheral blood progenitor cell mobilization for autologous and allogeneic hematopoietic cell transplantation: Guidelines from the american society for blood and marrow transplantation'. Together they form a unique fingerprint.

Cite this