Peripheral blood progenitor cell collections in multiple myeloma: Predictors and management of inadequate collections

H. Miles Prince, Kevin Imrie, D. Robert Sutherland, Armand Keating, Jacinta Meharchand, R. Michael Crump, Caroline Girouard, Kathy Trip, A. Keith Stewart

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Thirty-seven patients with previously treated multiple myeloma (MM) underwent peripheral blood progenitor cell (PBPC) collection following high-dose cyclophosphamide and GM-CSF or sequential IL-3 and GM-CSF. Patients with an inadequate collection were considered for a second or third collection. 25 patients underwent subsequent autotransplant. The only variable predictive of CFU-GM yield was the extent of prior melphalan therapy. All repeat collections were unsuccessful and patients infused with an autograft obtained from multiple sets of collections had a high incidence of delayed engraftment. We conclude that melphalan should be avoided or PBPC collection performed early in the disease course in patients who are potential transplant candidates.

Original languageEnglish (US)
Pages (from-to)142-145
Number of pages4
JournalBritish journal of haematology
Volume93
Issue number1
DOIs
StatePublished - May 2 1996

Keywords

  • haemopoietic stem cells
  • multiple myeloma
  • transplantation

ASJC Scopus subject areas

  • Hematology

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