Abstract
Thirty-seven patients with previously treated multiple myeloma (MM) underwent peripheral blood progenitor cell (PBPC) collection following high-dose cyclophosphamide and GM-CSF or sequential IL-3 and GM-CSF. Patients with an inadequate collection were considered for a second or third collection. 25 patients underwent subsequent autotransplant. The only variable predictive of CFU-GM yield was the extent of prior melphalan therapy. All repeat collections were unsuccessful and patients infused with an autograft obtained from multiple sets of collections had a high incidence of delayed engraftment. We conclude that melphalan should be avoided or PBPC collection performed early in the disease course in patients who are potential transplant candidates.
Original language | English (US) |
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Pages (from-to) | 142-145 |
Number of pages | 4 |
Journal | British journal of haematology |
Volume | 93 |
Issue number | 1 |
DOIs | |
State | Published - 1996 |
Keywords
- haemopoietic stem cells
- multiple myeloma
- transplantation
ASJC Scopus subject areas
- Hematology