Periosteum responds to dynamic fluid pressure by proliferating In vitro

D. B.F. Saris; A. Sanyal; K. N. An; J. S. Fitzsimmons; S. W. O'Driscoll

doi:10.1002/jor.1100170508

Periosteum responds to dynamic fluid pressure by proliferating In vitro

D. B.F. Saris, A. Sanyal, K. N. An, J. S. Fitzsimmons, S. W. O'Driscoll

Orthopedic Surgery

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53 Scopus citations

Abstract

The effect of dynamic fluid pressure on cell proliferation in periosteal tissue cultures was determined in explants from 60 immature New Zealand White rabbits. Dynamic fluid pressure increased proliferation of periosteal cells significantly, as indicated by a significant increase in [³H]thymidine uptake at all time points and a higher amount of DNA compared with control values. Cell proliferation in the early stages of chondrogenesis was stimulated by mechanical factors.

Original language	English (US)
Pages (from-to)	668-677
Number of pages	10
Journal	Journal of Orthopaedic Research
Volume	17
Issue number	5
DOIs	https://doi.org/10.1002/jor.1100170508
State	Published - 1999

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1002/jor.1100170508

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abstract = "The effect of dynamic fluid pressure on cell proliferation in periosteal tissue cultures was determined in explants from 60 immature New Zealand White rabbits. Dynamic fluid pressure increased proliferation of periosteal cells significantly, as indicated by a significant increase in [3H]thymidine uptake at all time points and a higher amount of DNA compared with control values. Cell proliferation in the early stages of chondrogenesis was stimulated by mechanical factors.",

author = "Saris, {D. B.F.} and A. Sanyal and An, {K. N.} and Fitzsimmons, {J. S.} and O'Driscoll, {S. W.}",

year = "1999",

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AU - Saris, D. B.F.

AU - Sanyal, A.

AU - An, K. N.

AU - Fitzsimmons, J. S.

AU - O'Driscoll, S. W.

PY - 1999

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N2 - The effect of dynamic fluid pressure on cell proliferation in periosteal tissue cultures was determined in explants from 60 immature New Zealand White rabbits. Dynamic fluid pressure increased proliferation of periosteal cells significantly, as indicated by a significant increase in [3H]thymidine uptake at all time points and a higher amount of DNA compared with control values. Cell proliferation in the early stages of chondrogenesis was stimulated by mechanical factors.

AB - The effect of dynamic fluid pressure on cell proliferation in periosteal tissue cultures was determined in explants from 60 immature New Zealand White rabbits. Dynamic fluid pressure increased proliferation of periosteal cells significantly, as indicated by a significant increase in [3H]thymidine uptake at all time points and a higher amount of DNA compared with control values. Cell proliferation in the early stages of chondrogenesis was stimulated by mechanical factors.

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Periosteum responds to dynamic fluid pressure by proliferating In vitro

Abstract

ASJC Scopus subject areas

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