Perioperative Management of Patients with Glioblastoma

Gaetano De Biase; Diogo P. Garcia; Angela Bohnen; Alfredo Quiñones-Hinojosa

doi:10.1016/j.nec.2020.09.005

Perioperative Management of Patients with Glioblastoma

Gaetano De Biase, Diogo P. Garcia, Angela Bohnen, Alfredo Quiñones-Hinojosa

Neurosurgery

Research output: Contribution to journal › Review article › peer-review

Abstract

The clinical presentation of glioblastomas is varied, and definitive diagnosis requires pathologic examination and study of the tissue. Management of glioblastomas includes surgery and adjuvant chemotherapy and radiotherapy, with surgery playing an important role in the prognosis of these patients. Awake craniotomy plays a crucial role in tumors in or adjacent to eloquent areas, allowing surgeons to maximize resection, while minimizing iatrogenic deficits. However, the prognosis remains dismal. This article presents the perioperative management of patients with glioblastoma including tools and surgical adjuncts to maximize extent of resection and minimize poor outcomes.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Neurosurgery clinics of North America
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.nec.2020.09.005
State	Published - Jan 2021

Keywords

Awake brain surgery
Glioblastoma
Temozolamide

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1016/j.nec.2020.09.005

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title = "Perioperative Management of Patients with Glioblastoma",

abstract = "The clinical presentation of glioblastomas is varied, and definitive diagnosis requires pathologic examination and study of the tissue. Management of glioblastomas includes surgery and adjuvant chemotherapy and radiotherapy, with surgery playing an important role in the prognosis of these patients. Awake craniotomy plays a crucial role in tumors in or adjacent to eloquent areas, allowing surgeons to maximize resection, while minimizing iatrogenic deficits. However, the prognosis remains dismal. This article presents the perioperative management of patients with glioblastoma including tools and surgical adjuncts to maximize extent of resection and minimize poor outcomes.",

keywords = "Awake brain surgery, Glioblastoma, Temozolamide",

author = "{De Biase}, Gaetano and Garcia, {Diogo P.} and Angela Bohnen and Alfredo Qui{\~n}ones-Hinojosa",

note = "Funding Information: Funding: A. Qui{\~n}ones-Hinojosa was supported by the Mayo Clinic Professorship and a Clinician Investigator award, and Florida State Department of Health Research Grant, and the Mayo Clinic Graduate School, as well as the National Institutes of Health ( R43CA221490 , R01CA200399 , R01CA195503 , and R01CA216855 ). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

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AU - De Biase, Gaetano

AU - Garcia, Diogo P.

AU - Bohnen, Angela

AU - Quiñones-Hinojosa, Alfredo

N1 - Funding Information: Funding: A. Quiñones-Hinojosa was supported by the Mayo Clinic Professorship and a Clinician Investigator award, and Florida State Department of Health Research Grant, and the Mayo Clinic Graduate School, as well as the National Institutes of Health ( R43CA221490 , R01CA200399 , R01CA195503 , and R01CA216855 ). Publisher Copyright: © 2020 Elsevier Inc.

PY - 2021/1

Y1 - 2021/1

N2 - The clinical presentation of glioblastomas is varied, and definitive diagnosis requires pathologic examination and study of the tissue. Management of glioblastomas includes surgery and adjuvant chemotherapy and radiotherapy, with surgery playing an important role in the prognosis of these patients. Awake craniotomy plays a crucial role in tumors in or adjacent to eloquent areas, allowing surgeons to maximize resection, while minimizing iatrogenic deficits. However, the prognosis remains dismal. This article presents the perioperative management of patients with glioblastoma including tools and surgical adjuncts to maximize extent of resection and minimize poor outcomes.

AB - The clinical presentation of glioblastomas is varied, and definitive diagnosis requires pathologic examination and study of the tissue. Management of glioblastomas includes surgery and adjuvant chemotherapy and radiotherapy, with surgery playing an important role in the prognosis of these patients. Awake craniotomy plays a crucial role in tumors in or adjacent to eloquent areas, allowing surgeons to maximize resection, while minimizing iatrogenic deficits. However, the prognosis remains dismal. This article presents the perioperative management of patients with glioblastoma including tools and surgical adjuncts to maximize extent of resection and minimize poor outcomes.

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KW - Glioblastoma

KW - Temozolamide

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Perioperative Management of Patients with Glioblastoma

Abstract

Keywords

ASJC Scopus subject areas

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