Perioperative hypothermia (33°C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: Findings from the intraoperative hypothermia for aneurysm surgery trial

Hoang P. Nguyen, Jonathan G. Zaroff, Emine O. Bayman, Adrian W. Gelb, Michael M. Todd, Bradley J. Hindman, M. Todd, B. Hindman, W. Clarke, K. Chaloner, J. Torner, P. Davis, M. Howard, D. Tranel, S. Anderson, J. Weeks, L. Moss, J. Winn, W. Clarke, K. ChalonerM. Wichman, R. Peters, M. Hansen, D. Anderson, J. Lang, B. Yoo, H. Adams, G. Clifton, A. Gelb, W. Young, C. Loftus, A. Schubert, D. Warner, R. Frankowski, K. Kieburtz, D. Prough, L. Sternau, J. Marler, C. Moy, B. Radziszewska, B. Hindman, J. Zaroff, L. Coghlan, R. Craen, T. Short, R. Greif, F. Meyer, J. Atkinson, M. Link, M. Trenerry

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Perioperative hypothermia has been reported to increase the occurrence of cardiovascular complications. By increasing the activity of sympathetic nervous system, perioperative hypothermia also has the potential to increase cardiac injury and dysfunction associated with subarachnoid hemorrhage. Methods: The Intraoperative Hypothermia for Aneurysm Surgery Trial randomized patients undergoing cerebral aneurysm surgery to intraoperative hypothermia (n = 499, 33.3° ± 0.8°C) or normothermia (n = 501, 36.7° ± 0.5°C). Cardiovascular events (hypotension, arrhythmias, vasopressor use, myocardial infarction, and others) were prospectively followed until 3-month follow-up and were compared in hypothermic and normothermic patients. A subset of 62 patients (hypothermia, n = 33; normothermia, n = 29) also had preoperative and postoperative (within 24 h) measurement of cardiac troponin-I and echocardiography to explore the association between perioperative hypothermia and subarachnoid hemorrhage-associated myocardial injury and left ventricular function. Results: There was no difference between hypothermic and normothermic patients in the occurrence of any single cardiovascular event or in composite cardiovascular events. There was no difference in mortality (6%) between groups, and there was only a single primary cardiovascular death (normothermia). There was no difference between hypothermic and normothermic patients in postoperative versus preoperative left ventricular regional wall motion or ejection fraction. Compared with preoperative values, hypothermic patients had no postoperative increase in cardiac troponin-I (median change 0.00 μg/l), whereas normothermic patients had a small postoperative increase (median change + 0.01 μg/l, P = 0.038). Conclusion: In patients undergoing cerebral aneurysm surgery, perioperative hypothermia was not associated with an increased occurrence of cardiovascular events.

Original languageEnglish (US)
Pages (from-to)327-342
Number of pages16
JournalAnesthesiology
Volume113
Issue number2
DOIs
StatePublished - Aug 2010
Externally publishedYes

Fingerprint

Intracranial Aneurysm
Hypothermia
Aneurysm
Troponin I
Subarachnoid Hemorrhage
Sympathetic Nervous System
Wounds and Injuries
Left Ventricular Function
Hypotension
Echocardiography
Cardiac Arrhythmias
Myocardial Infarction
Mortality

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Perioperative hypothermia (33°C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery : Findings from the intraoperative hypothermia for aneurysm surgery trial. / Nguyen, Hoang P.; Zaroff, Jonathan G.; Bayman, Emine O.; Gelb, Adrian W.; Todd, Michael M.; Hindman, Bradley J.; Todd, M.; Hindman, B.; Clarke, W.; Chaloner, K.; Torner, J.; Davis, P.; Howard, M.; Tranel, D.; Anderson, S.; Weeks, J.; Moss, L.; Winn, J.; Clarke, W.; Chaloner, K.; Wichman, M.; Peters, R.; Hansen, M.; Anderson, D.; Lang, J.; Yoo, B.; Adams, H.; Clifton, G.; Gelb, A.; Young, W.; Loftus, C.; Schubert, A.; Warner, D.; Frankowski, R.; Kieburtz, K.; Prough, D.; Sternau, L.; Marler, J.; Moy, C.; Radziszewska, B.; Hindman, B.; Zaroff, J.; Coghlan, L.; Craen, R.; Short, T.; Greif, R.; Meyer, F.; Atkinson, J.; Link, M.; Trenerry, M.

In: Anesthesiology, Vol. 113, No. 2, 08.2010, p. 327-342.

Research output: Contribution to journalArticle

Nguyen, HP, Zaroff, JG, Bayman, EO, Gelb, AW, Todd, MM, Hindman, BJ, Todd, M, Hindman, B, Clarke, W, Chaloner, K, Torner, J, Davis, P, Howard, M, Tranel, D, Anderson, S, Weeks, J, Moss, L, Winn, J, Clarke, W, Chaloner, K, Wichman, M, Peters, R, Hansen, M, Anderson, D, Lang, J, Yoo, B, Adams, H, Clifton, G, Gelb, A, Young, W, Loftus, C, Schubert, A, Warner, D, Frankowski, R, Kieburtz, K, Prough, D, Sternau, L, Marler, J, Moy, C, Radziszewska, B, Hindman, B, Zaroff, J, Coghlan, L, Craen, R, Short, T, Greif, R, Meyer, F, Atkinson, J, Link, M & Trenerry, M 2010, 'Perioperative hypothermia (33°C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: Findings from the intraoperative hypothermia for aneurysm surgery trial', Anesthesiology, vol. 113, no. 2, pp. 327-342. https://doi.org/10.1097/ALN.0b013e3181dfd4f7
Nguyen, Hoang P. ; Zaroff, Jonathan G. ; Bayman, Emine O. ; Gelb, Adrian W. ; Todd, Michael M. ; Hindman, Bradley J. ; Todd, M. ; Hindman, B. ; Clarke, W. ; Chaloner, K. ; Torner, J. ; Davis, P. ; Howard, M. ; Tranel, D. ; Anderson, S. ; Weeks, J. ; Moss, L. ; Winn, J. ; Clarke, W. ; Chaloner, K. ; Wichman, M. ; Peters, R. ; Hansen, M. ; Anderson, D. ; Lang, J. ; Yoo, B. ; Adams, H. ; Clifton, G. ; Gelb, A. ; Young, W. ; Loftus, C. ; Schubert, A. ; Warner, D. ; Frankowski, R. ; Kieburtz, K. ; Prough, D. ; Sternau, L. ; Marler, J. ; Moy, C. ; Radziszewska, B. ; Hindman, B. ; Zaroff, J. ; Coghlan, L. ; Craen, R. ; Short, T. ; Greif, R. ; Meyer, F. ; Atkinson, J. ; Link, M. ; Trenerry, M. / Perioperative hypothermia (33°C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery : Findings from the intraoperative hypothermia for aneurysm surgery trial. In: Anesthesiology. 2010 ; Vol. 113, No. 2. pp. 327-342.
@article{06700cb1320e495aa30307eead341171,
title = "Perioperative hypothermia (33°C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: Findings from the intraoperative hypothermia for aneurysm surgery trial",
abstract = "Background: Perioperative hypothermia has been reported to increase the occurrence of cardiovascular complications. By increasing the activity of sympathetic nervous system, perioperative hypothermia also has the potential to increase cardiac injury and dysfunction associated with subarachnoid hemorrhage. Methods: The Intraoperative Hypothermia for Aneurysm Surgery Trial randomized patients undergoing cerebral aneurysm surgery to intraoperative hypothermia (n = 499, 33.3° ± 0.8°C) or normothermia (n = 501, 36.7° ± 0.5°C). Cardiovascular events (hypotension, arrhythmias, vasopressor use, myocardial infarction, and others) were prospectively followed until 3-month follow-up and were compared in hypothermic and normothermic patients. A subset of 62 patients (hypothermia, n = 33; normothermia, n = 29) also had preoperative and postoperative (within 24 h) measurement of cardiac troponin-I and echocardiography to explore the association between perioperative hypothermia and subarachnoid hemorrhage-associated myocardial injury and left ventricular function. Results: There was no difference between hypothermic and normothermic patients in the occurrence of any single cardiovascular event or in composite cardiovascular events. There was no difference in mortality (6{\%}) between groups, and there was only a single primary cardiovascular death (normothermia). There was no difference between hypothermic and normothermic patients in postoperative versus preoperative left ventricular regional wall motion or ejection fraction. Compared with preoperative values, hypothermic patients had no postoperative increase in cardiac troponin-I (median change 0.00 μg/l), whereas normothermic patients had a small postoperative increase (median change + 0.01 μg/l, P = 0.038). Conclusion: In patients undergoing cerebral aneurysm surgery, perioperative hypothermia was not associated with an increased occurrence of cardiovascular events.",
author = "Nguyen, {Hoang P.} and Zaroff, {Jonathan G.} and Bayman, {Emine O.} and Gelb, {Adrian W.} and Todd, {Michael M.} and Hindman, {Bradley J.} and M. Todd and B. Hindman and W. Clarke and K. Chaloner and J. Torner and P. Davis and M. Howard and D. Tranel and S. Anderson and J. Weeks and L. Moss and J. Winn and W. Clarke and K. Chaloner and M. Wichman and R. Peters and M. Hansen and D. Anderson and J. Lang and B. Yoo and H. Adams and G. Clifton and A. Gelb and W. Young and C. Loftus and A. Schubert and D. Warner and R. Frankowski and K. Kieburtz and D. Prough and L. Sternau and J. Marler and C. Moy and B. Radziszewska and B. Hindman and J. Zaroff and L. Coghlan and R. Craen and T. Short and R. Greif and F. Meyer and J. Atkinson and M. Link and M. Trenerry",
year = "2010",
month = "8",
doi = "10.1097/ALN.0b013e3181dfd4f7",
language = "English (US)",
volume = "113",
pages = "327--342",
journal = "Anesthesiology",
issn = "0003-3022",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Perioperative hypothermia (33°C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery

T2 - Findings from the intraoperative hypothermia for aneurysm surgery trial

AU - Nguyen, Hoang P.

AU - Zaroff, Jonathan G.

AU - Bayman, Emine O.

AU - Gelb, Adrian W.

AU - Todd, Michael M.

AU - Hindman, Bradley J.

AU - Todd, M.

AU - Hindman, B.

AU - Clarke, W.

AU - Chaloner, K.

AU - Torner, J.

AU - Davis, P.

AU - Howard, M.

AU - Tranel, D.

AU - Anderson, S.

AU - Weeks, J.

AU - Moss, L.

AU - Winn, J.

AU - Clarke, W.

AU - Chaloner, K.

AU - Wichman, M.

AU - Peters, R.

AU - Hansen, M.

AU - Anderson, D.

AU - Lang, J.

AU - Yoo, B.

AU - Adams, H.

AU - Clifton, G.

AU - Gelb, A.

AU - Young, W.

AU - Loftus, C.

AU - Schubert, A.

AU - Warner, D.

AU - Frankowski, R.

AU - Kieburtz, K.

AU - Prough, D.

AU - Sternau, L.

AU - Marler, J.

AU - Moy, C.

AU - Radziszewska, B.

AU - Hindman, B.

AU - Zaroff, J.

AU - Coghlan, L.

AU - Craen, R.

AU - Short, T.

AU - Greif, R.

AU - Meyer, F.

AU - Atkinson, J.

AU - Link, M.

AU - Trenerry, M.

PY - 2010/8

Y1 - 2010/8

N2 - Background: Perioperative hypothermia has been reported to increase the occurrence of cardiovascular complications. By increasing the activity of sympathetic nervous system, perioperative hypothermia also has the potential to increase cardiac injury and dysfunction associated with subarachnoid hemorrhage. Methods: The Intraoperative Hypothermia for Aneurysm Surgery Trial randomized patients undergoing cerebral aneurysm surgery to intraoperative hypothermia (n = 499, 33.3° ± 0.8°C) or normothermia (n = 501, 36.7° ± 0.5°C). Cardiovascular events (hypotension, arrhythmias, vasopressor use, myocardial infarction, and others) were prospectively followed until 3-month follow-up and were compared in hypothermic and normothermic patients. A subset of 62 patients (hypothermia, n = 33; normothermia, n = 29) also had preoperative and postoperative (within 24 h) measurement of cardiac troponin-I and echocardiography to explore the association between perioperative hypothermia and subarachnoid hemorrhage-associated myocardial injury and left ventricular function. Results: There was no difference between hypothermic and normothermic patients in the occurrence of any single cardiovascular event or in composite cardiovascular events. There was no difference in mortality (6%) between groups, and there was only a single primary cardiovascular death (normothermia). There was no difference between hypothermic and normothermic patients in postoperative versus preoperative left ventricular regional wall motion or ejection fraction. Compared with preoperative values, hypothermic patients had no postoperative increase in cardiac troponin-I (median change 0.00 μg/l), whereas normothermic patients had a small postoperative increase (median change + 0.01 μg/l, P = 0.038). Conclusion: In patients undergoing cerebral aneurysm surgery, perioperative hypothermia was not associated with an increased occurrence of cardiovascular events.

AB - Background: Perioperative hypothermia has been reported to increase the occurrence of cardiovascular complications. By increasing the activity of sympathetic nervous system, perioperative hypothermia also has the potential to increase cardiac injury and dysfunction associated with subarachnoid hemorrhage. Methods: The Intraoperative Hypothermia for Aneurysm Surgery Trial randomized patients undergoing cerebral aneurysm surgery to intraoperative hypothermia (n = 499, 33.3° ± 0.8°C) or normothermia (n = 501, 36.7° ± 0.5°C). Cardiovascular events (hypotension, arrhythmias, vasopressor use, myocardial infarction, and others) were prospectively followed until 3-month follow-up and were compared in hypothermic and normothermic patients. A subset of 62 patients (hypothermia, n = 33; normothermia, n = 29) also had preoperative and postoperative (within 24 h) measurement of cardiac troponin-I and echocardiography to explore the association between perioperative hypothermia and subarachnoid hemorrhage-associated myocardial injury and left ventricular function. Results: There was no difference between hypothermic and normothermic patients in the occurrence of any single cardiovascular event or in composite cardiovascular events. There was no difference in mortality (6%) between groups, and there was only a single primary cardiovascular death (normothermia). There was no difference between hypothermic and normothermic patients in postoperative versus preoperative left ventricular regional wall motion or ejection fraction. Compared with preoperative values, hypothermic patients had no postoperative increase in cardiac troponin-I (median change 0.00 μg/l), whereas normothermic patients had a small postoperative increase (median change + 0.01 μg/l, P = 0.038). Conclusion: In patients undergoing cerebral aneurysm surgery, perioperative hypothermia was not associated with an increased occurrence of cardiovascular events.

UR - http://www.scopus.com/inward/record.url?scp=77955177076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955177076&partnerID=8YFLogxK

U2 - 10.1097/ALN.0b013e3181dfd4f7

DO - 10.1097/ALN.0b013e3181dfd4f7

M3 - Article

C2 - 20571361

AN - SCOPUS:77955177076

VL - 113

SP - 327

EP - 342

JO - Anesthesiology

JF - Anesthesiology

SN - 0003-3022

IS - 2

ER -