Perioperative Diabetes Insipidus Caused by Anesthetic Medications: A Review of the Literature

Lauren M. Van Decar; Emily G. Reynolds; Emily E. Sharpe; Monica W. Harbell; Heidi E. Kosiorek; Molly B. Kraus

doi:10.1213/ANE.0000000000005344

Perioperative Diabetes Insipidus Caused by Anesthetic Medications: A Review of the Literature

Lauren M. Van Decar, Emily G. Reynolds, Emily E. Sharpe, Monica W. Harbell, Heidi E. Kosiorek, Molly B. Kraus

Anesthesiology

Research output: Contribution to journal › Review article › peer-review

Abstract

Diabetes insipidus (DI) is an uncommon perioperative complication that can occur secondary to medications or surgical manipulation and can cause significant hypovolemia and electrolyte abnormalities. We reviewed and evaluated the current literature and identified 29 cases of DI related to medications commonly used in anesthesia such as propofol, dexmedetomidine, sevoflurane, ketamine, and opioids. This review summarizes the case reports and frequency of DI with each medication and presents possible pathophysiology. Medication-induced DI should be included in the differential diagnosis when intraoperative polyuria is identified. Early identification, removal of the agent, and treatment of intraoperative DI are critical to minimize complications.

Original language	English (US)
Pages (from-to)	82-89
Number of pages	8
Journal	Anesthesia and analgesia
Volume	134
Issue number	1
DOIs	https://doi.org/10.1213/ANE.0000000000005344
State	Published - Jan 1 2022

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1213/ANE.0000000000005344

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title = "Perioperative Diabetes Insipidus Caused by Anesthetic Medications: A Review of the Literature",

abstract = "Diabetes insipidus (DI) is an uncommon perioperative complication that can occur secondary to medications or surgical manipulation and can cause significant hypovolemia and electrolyte abnormalities. We reviewed and evaluated the current literature and identified 29 cases of DI related to medications commonly used in anesthesia such as propofol, dexmedetomidine, sevoflurane, ketamine, and opioids. This review summarizes the case reports and frequency of DI with each medication and presents possible pathophysiology. Medication-induced DI should be included in the differential diagnosis when intraoperative polyuria is identified. Early identification, removal of the agent, and treatment of intraoperative DI are critical to minimize complications.",

author = "{Van Decar}, {Lauren M.} and Reynolds, {Emily G.} and Sharpe, {Emily E.} and Harbell, {Monica W.} and Kosiorek, {Heidi E.} and Kraus, {Molly B.}",

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AU - Van Decar, Lauren M.

AU - Reynolds, Emily G.

AU - Sharpe, Emily E.

AU - Harbell, Monica W.

AU - Kosiorek, Heidi E.

AU - Kraus, Molly B.

PY - 2022/1/1

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N2 - Diabetes insipidus (DI) is an uncommon perioperative complication that can occur secondary to medications or surgical manipulation and can cause significant hypovolemia and electrolyte abnormalities. We reviewed and evaluated the current literature and identified 29 cases of DI related to medications commonly used in anesthesia such as propofol, dexmedetomidine, sevoflurane, ketamine, and opioids. This review summarizes the case reports and frequency of DI with each medication and presents possible pathophysiology. Medication-induced DI should be included in the differential diagnosis when intraoperative polyuria is identified. Early identification, removal of the agent, and treatment of intraoperative DI are critical to minimize complications.

AB - Diabetes insipidus (DI) is an uncommon perioperative complication that can occur secondary to medications or surgical manipulation and can cause significant hypovolemia and electrolyte abnormalities. We reviewed and evaluated the current literature and identified 29 cases of DI related to medications commonly used in anesthesia such as propofol, dexmedetomidine, sevoflurane, ketamine, and opioids. This review summarizes the case reports and frequency of DI with each medication and presents possible pathophysiology. Medication-induced DI should be included in the differential diagnosis when intraoperative polyuria is identified. Early identification, removal of the agent, and treatment of intraoperative DI are critical to minimize complications.

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Perioperative Diabetes Insipidus Caused by Anesthetic Medications: A Review of the Literature

Abstract

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