Perioperative allogeneic nonleukoreduced blood transfusion and prostate cancer outcomes after radical prostatectomy

Tze Yeng Yeoh, Federica Scavonetto, Toby N. Weingarten, R. Jeffrey Karnes, Camille M. Van Buskirk, Andrew C. Hanson, Darrell R. Schroeder, Juraj Sprung

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

BACKGROUND: Allogeneic blood transfusion induces immunosuppression, and concern has been raised that it may increase propensity for cancer recurrence; however, these effects have not been confirmed. We examined the association of perioperative transfusion of allogeneic blood long-term oncologic outcomes in patients with prostate cancer who underwent prostatectomy. STUDY DESIGN AND METHODS: We reviewed medical records of patients who underwent radical prostatectomy between 1991 and 2005 and received allogeneic nonleukoreduced blood. Each transfused patient was matched to two controls who did not receive blood: matching included age, surgical year, prostate-specific antigen level, pathologic tumor stages, pathologic Gleason scores, and anesthetic type. Primary outcome was systemic tumor progression, with secondary outcomes of prostate cancer death and all-cause mortality. Stratified proportional hazards regression analysis was used to assess differences in outcomes between the transfused and nontransfused group. RESULTS: A total of 379 prostatectomy patients who were transfused and 758 nontransfused controls were followed for 9.4 and 10.2 years (median), respectively. In a multivariable analysis that took into account the matched study design and adjusted for positive surgical margins and adjuvant therapies, the use of allogeneic blood was not associated with systemic tumor progression (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.39-1.99; p = 0.76), prostate cancer-specific death (HR, 1.69; 95% CI, 0.44 to 6.48; p = 0.44), or allcause death (HR, 1.20; 95% CI, 0.87 to 1.67; p = 0.27). CONCLUSIONS: When adjusted for clinicopathologic and procedural variables transfusion of allogeneic blood was not associated with systemic tumor progression and survival outcomes.

Original languageEnglish (US)
Pages (from-to)2175-2181
Number of pages7
JournalTransfusion
Volume54
Issue number9
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

Fingerprint Dive into the research topics of 'Perioperative allogeneic nonleukoreduced blood transfusion and prostate cancer outcomes after radical prostatectomy'. Together they form a unique fingerprint.

Cite this