Perineural spread of cervical cancer to the sciatic nerve

Benjamin Matthew Howe, Kimberly K. Amrami, Mark A. Nathan, Joaquin J. Garcia, Robert J. Spinner

Research output: Contribution to journalReview article

15 Scopus citations


In this report we present a patient with a recent diagnosis of cervical adenocarcinoma with progressive left lower extremity pain and weakness. MR imaging of the pelvis and subsequent FDG CT/PET were complementary in demonstrating abnormalities worrisome for perineural spread of malignancy, which was confirmed with an open fascicular biopsy of the sciatic nerve. We review the imaging and propose a mechanism of perineural spread to the sciatic nerve, which we believe is supported by the imaging in this case.

Original languageEnglish (US)
Pages (from-to)1627-1631
Number of pages5
JournalSkeletal Radiology
Issue number11
StatePublished - 2013



  • Malignant plexopathy
  • Perineural malignancy
  • Perineural sciatic

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Howe, B. M., Amrami, K. K., Nathan, M. A., Garcia, J. J., & Spinner, R. J. (2013). Perineural spread of cervical cancer to the sciatic nerve. Skeletal Radiology, 42(11), 1627-1631.