Perineural spread in pelvic malignancies can be an alternate explanation for pelvic bony metastases rather than hematogenous spread. A report of two cases

Stepan Capek, Benjamin M. Howe, Adam T. Froemming, Kimberly K. Amrami, Robert J. Spinner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We propose that pelvic malignancies can spread to bone and cause bony metastases using nerves as conduits. We reviewed two cases of pelvic malignancy with perineural spread of bladder cancer and prostate cancer. In a patient with prostate cancer, we identified six lesions that were positive on the 11C-choline PET/CT scan and MRI; in a patient with bladder cancer, we identified two lesions positive on the 18F-deoxy-glucose PET/CT scan and MRI. We carefully reviewed the imaging studies, and using established sclerotome maps we identified spinal nerves supplying each of eight pelvic bony lesions. All these spinal nerves showed evidence of tumor infiltration with extension toward the affected bones. We theorize that perineural tumor spread may serve as an additional mechanism of pelvic osseous metastases in pelvic malignancies.

Original languageEnglish (US)
Pages (from-to)1365-1370
Number of pages6
JournalSkeletal Radiology
Volume44
Issue number9
DOIs
StatePublished - Oct 27 2015

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Neoplasm Metastasis
Spinal Nerves
Prostatic Neoplasms
Neoplasms
Urinary Bladder Neoplasms
Bone and Bones
Choline
Glucose
Positron Emission Tomography Computed Tomography

Keywords

  • Bladder cancer
  • Bone metastasis
  • Perineural spread
  • Prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Perineural spread in pelvic malignancies can be an alternate explanation for pelvic bony metastases rather than hematogenous spread. A report of two cases. / Capek, Stepan; Howe, Benjamin M.; Froemming, Adam T.; Amrami, Kimberly K.; Spinner, Robert J.

In: Skeletal Radiology, Vol. 44, No. 9, 27.10.2015, p. 1365-1370.

Research output: Contribution to journalArticle

Capek, Stepan ; Howe, Benjamin M. ; Froemming, Adam T. ; Amrami, Kimberly K. ; Spinner, Robert J. / Perineural spread in pelvic malignancies can be an alternate explanation for pelvic bony metastases rather than hematogenous spread. A report of two cases. In: Skeletal Radiology. 2015 ; Vol. 44, No. 9. pp. 1365-1370.
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