Abstract
Lung diseases, such as bronchopulmonary dysplasia (BPD), wheezing, and asthma, remain significant causes of morbidity and mortality in the pediatric population, particularly in the setting of premature birth. Pulmonary outcomes in these infants are highly influenced by perinatal exposures including prenatal inflammation, postnatal intensive care unit interventions, and environmental agents. Here, there is strong evidence that perinatal supplemental oxygen administration has significant effects on pulmonary development and health. This is of particular importance in the preterm lung, where premature exposure to room air represents a hyperoxic insult that may cause harm to a lung primed to develop in a hypoxic environment. Preterm infants are also subject to increased episodes of hypoxia, which may also result in pulmonary damage and disease. Here, we summarize the current understanding of the effects of oxygen on the developing lung andhowlow vs. high oxygenmaypredispose to pulmonary disease thatmayextend even into adulthood. Better understanding of the underlying mechanisms will help lead to improved care and outcomes in this vulnerable population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 119-127 |
| Number of pages | 9 |
| Journal | Canadian Journal of Physiology and Pharmacology |
| Volume | 93 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 19 2014 |
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Keywords
- Asthma
- Bronchopulmonary dysplasia
- Hyperoxia
- Hypoxia
- Neonatal
ASJC Scopus subject areas
- Medicine(all)
- Physiology
- Pharmacology
- Physiology (medical)
Cite this
Perinatal oxygen in the developing lung. / Vogel, Elizabeth R.; Britt, Rodney Jr.; Trinidad, Mari Charisse; Faksh, Arij; Martin, Richard J.; MacFarlane, Peter M.; Pabelick, Christina M; Prakash, Y.s.
In: Canadian Journal of Physiology and Pharmacology, Vol. 93, No. 2, 19.11.2014, p. 119-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Perinatal oxygen in the developing lung
AU - Vogel, Elizabeth R.
AU - Britt, Rodney Jr.
AU - Trinidad, Mari Charisse
AU - Faksh, Arij
AU - Martin, Richard J.
AU - MacFarlane, Peter M.
AU - Pabelick, Christina M
AU - Prakash, Y.s.
PY - 2014/11/19
Y1 - 2014/11/19
N2 - Lung diseases, such as bronchopulmonary dysplasia (BPD), wheezing, and asthma, remain significant causes of morbidity and mortality in the pediatric population, particularly in the setting of premature birth. Pulmonary outcomes in these infants are highly influenced by perinatal exposures including prenatal inflammation, postnatal intensive care unit interventions, and environmental agents. Here, there is strong evidence that perinatal supplemental oxygen administration has significant effects on pulmonary development and health. This is of particular importance in the preterm lung, where premature exposure to room air represents a hyperoxic insult that may cause harm to a lung primed to develop in a hypoxic environment. Preterm infants are also subject to increased episodes of hypoxia, which may also result in pulmonary damage and disease. Here, we summarize the current understanding of the effects of oxygen on the developing lung andhowlow vs. high oxygenmaypredispose to pulmonary disease thatmayextend even into adulthood. Better understanding of the underlying mechanisms will help lead to improved care and outcomes in this vulnerable population.
AB - Lung diseases, such as bronchopulmonary dysplasia (BPD), wheezing, and asthma, remain significant causes of morbidity and mortality in the pediatric population, particularly in the setting of premature birth. Pulmonary outcomes in these infants are highly influenced by perinatal exposures including prenatal inflammation, postnatal intensive care unit interventions, and environmental agents. Here, there is strong evidence that perinatal supplemental oxygen administration has significant effects on pulmonary development and health. This is of particular importance in the preterm lung, where premature exposure to room air represents a hyperoxic insult that may cause harm to a lung primed to develop in a hypoxic environment. Preterm infants are also subject to increased episodes of hypoxia, which may also result in pulmonary damage and disease. Here, we summarize the current understanding of the effects of oxygen on the developing lung andhowlow vs. high oxygenmaypredispose to pulmonary disease thatmayextend even into adulthood. Better understanding of the underlying mechanisms will help lead to improved care and outcomes in this vulnerable population.
KW - Asthma
KW - Bronchopulmonary dysplasia
KW - Hyperoxia
KW - Hypoxia
KW - Neonatal
UR - http://www.scopus.com/inward/record.url?scp=84961287990&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961287990&partnerID=8YFLogxK
U2 - 10.1139/cjpp-2014-0387
DO - 10.1139/cjpp-2014-0387
M3 - Article
C2 - 25594569
AN - SCOPUS:84961287990
VL - 93
SP - 119
EP - 127
JO - Canadian Journal of Physiology and Pharmacology
JF - Canadian Journal of Physiology and Pharmacology
SN - 0008-4212
IS - 2
ER -