Perinatal oxygen in the developing lung

Elizabeth R. Vogel, Rodney Jr. Britt, Mari Charisse Trinidad, Arij Faksh, Richard J. Martin, Peter M. MacFarlane, Christina M Pabelick, Y.s. Prakash

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Lung diseases, such as bronchopulmonary dysplasia (BPD), wheezing, and asthma, remain significant causes of morbidity and mortality in the pediatric population, particularly in the setting of premature birth. Pulmonary outcomes in these infants are highly influenced by perinatal exposures including prenatal inflammation, postnatal intensive care unit interventions, and environmental agents. Here, there is strong evidence that perinatal supplemental oxygen administration has significant effects on pulmonary development and health. This is of particular importance in the preterm lung, where premature exposure to room air represents a hyperoxic insult that may cause harm to a lung primed to develop in a hypoxic environment. Preterm infants are also subject to increased episodes of hypoxia, which may also result in pulmonary damage and disease. Here, we summarize the current understanding of the effects of oxygen on the developing lung andhowlow vs. high oxygenmaypredispose to pulmonary disease thatmayextend even into adulthood. Better understanding of the underlying mechanisms will help lead to improved care and outcomes in this vulnerable population.

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalCanadian Journal of Physiology and Pharmacology
Volume93
Issue number2
DOIs
StatePublished - Nov 19 2014

Fingerprint

Oxygen
Lung
Lung Diseases
Postnatal Care
Bronchopulmonary Dysplasia
Respiratory Sounds
Premature Birth
Vulnerable Populations
Premature Infants
Intensive Care Units
Asthma
Air
Pediatrics
Inflammation
Morbidity
Mortality
Health
Population

Keywords

  • Asthma
  • Bronchopulmonary dysplasia
  • Hyperoxia
  • Hypoxia
  • Neonatal

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Perinatal oxygen in the developing lung. / Vogel, Elizabeth R.; Britt, Rodney Jr.; Trinidad, Mari Charisse; Faksh, Arij; Martin, Richard J.; MacFarlane, Peter M.; Pabelick, Christina M; Prakash, Y.s.

In: Canadian Journal of Physiology and Pharmacology, Vol. 93, No. 2, 19.11.2014, p. 119-127.

Research output: Contribution to journalArticle

Vogel ER, Britt RJ, Trinidad MC, Faksh A, Martin RJ, MacFarlane PM et al. Perinatal oxygen in the developing lung. Canadian Journal of Physiology and Pharmacology. 2014 Nov 19;93(2):119-127. https://doi.org/10.1139/cjpp-2014-0387
Vogel, Elizabeth R. ; Britt, Rodney Jr. ; Trinidad, Mari Charisse ; Faksh, Arij ; Martin, Richard J. ; MacFarlane, Peter M. ; Pabelick, Christina M ; Prakash, Y.s. / Perinatal oxygen in the developing lung. In: Canadian Journal of Physiology and Pharmacology. 2014 ; Vol. 93, No. 2. pp. 119-127.
@article{477924e244e146c0b27c22a9492dff94,
title = "Perinatal oxygen in the developing lung",
abstract = "Lung diseases, such as bronchopulmonary dysplasia (BPD), wheezing, and asthma, remain significant causes of morbidity and mortality in the pediatric population, particularly in the setting of premature birth. Pulmonary outcomes in these infants are highly influenced by perinatal exposures including prenatal inflammation, postnatal intensive care unit interventions, and environmental agents. Here, there is strong evidence that perinatal supplemental oxygen administration has significant effects on pulmonary development and health. This is of particular importance in the preterm lung, where premature exposure to room air represents a hyperoxic insult that may cause harm to a lung primed to develop in a hypoxic environment. Preterm infants are also subject to increased episodes of hypoxia, which may also result in pulmonary damage and disease. Here, we summarize the current understanding of the effects of oxygen on the developing lung andhowlow vs. high oxygenmaypredispose to pulmonary disease thatmayextend even into adulthood. Better understanding of the underlying mechanisms will help lead to improved care and outcomes in this vulnerable population.",
keywords = "Asthma, Bronchopulmonary dysplasia, Hyperoxia, Hypoxia, Neonatal",
author = "Vogel, {Elizabeth R.} and Britt, {Rodney Jr.} and Trinidad, {Mari Charisse} and Arij Faksh and Martin, {Richard J.} and MacFarlane, {Peter M.} and Pabelick, {Christina M} and Y.s. Prakash",
year = "2014",
month = "11",
day = "19",
doi = "10.1139/cjpp-2014-0387",
language = "English (US)",
volume = "93",
pages = "119--127",
journal = "Canadian Journal of Physiology and Pharmacology",
issn = "0008-4212",
publisher = "National Research Council of Canada",
number = "2",

}

TY - JOUR

T1 - Perinatal oxygen in the developing lung

AU - Vogel, Elizabeth R.

AU - Britt, Rodney Jr.

AU - Trinidad, Mari Charisse

AU - Faksh, Arij

AU - Martin, Richard J.

AU - MacFarlane, Peter M.

AU - Pabelick, Christina M

AU - Prakash, Y.s.

PY - 2014/11/19

Y1 - 2014/11/19

N2 - Lung diseases, such as bronchopulmonary dysplasia (BPD), wheezing, and asthma, remain significant causes of morbidity and mortality in the pediatric population, particularly in the setting of premature birth. Pulmonary outcomes in these infants are highly influenced by perinatal exposures including prenatal inflammation, postnatal intensive care unit interventions, and environmental agents. Here, there is strong evidence that perinatal supplemental oxygen administration has significant effects on pulmonary development and health. This is of particular importance in the preterm lung, where premature exposure to room air represents a hyperoxic insult that may cause harm to a lung primed to develop in a hypoxic environment. Preterm infants are also subject to increased episodes of hypoxia, which may also result in pulmonary damage and disease. Here, we summarize the current understanding of the effects of oxygen on the developing lung andhowlow vs. high oxygenmaypredispose to pulmonary disease thatmayextend even into adulthood. Better understanding of the underlying mechanisms will help lead to improved care and outcomes in this vulnerable population.

AB - Lung diseases, such as bronchopulmonary dysplasia (BPD), wheezing, and asthma, remain significant causes of morbidity and mortality in the pediatric population, particularly in the setting of premature birth. Pulmonary outcomes in these infants are highly influenced by perinatal exposures including prenatal inflammation, postnatal intensive care unit interventions, and environmental agents. Here, there is strong evidence that perinatal supplemental oxygen administration has significant effects on pulmonary development and health. This is of particular importance in the preterm lung, where premature exposure to room air represents a hyperoxic insult that may cause harm to a lung primed to develop in a hypoxic environment. Preterm infants are also subject to increased episodes of hypoxia, which may also result in pulmonary damage and disease. Here, we summarize the current understanding of the effects of oxygen on the developing lung andhowlow vs. high oxygenmaypredispose to pulmonary disease thatmayextend even into adulthood. Better understanding of the underlying mechanisms will help lead to improved care and outcomes in this vulnerable population.

KW - Asthma

KW - Bronchopulmonary dysplasia

KW - Hyperoxia

KW - Hypoxia

KW - Neonatal

UR - http://www.scopus.com/inward/record.url?scp=84961287990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961287990&partnerID=8YFLogxK

U2 - 10.1139/cjpp-2014-0387

DO - 10.1139/cjpp-2014-0387

M3 - Article

C2 - 25594569

AN - SCOPUS:84961287990

VL - 93

SP - 119

EP - 127

JO - Canadian Journal of Physiology and Pharmacology

JF - Canadian Journal of Physiology and Pharmacology

SN - 0008-4212

IS - 2

ER -