Perinatal outcomes of fetal intra-abdominal umbilical vein varix: a multicenter cohort study

Victoria Novoa, Sherif Shazly, Eniola R. Ibirogba, Laura Sutton, Gabriele Tonni, Federico Prefumo, Waldo Sepulveda, Edward Araujo Júnior, Heron Werner, Mari Charisse Trinidad, Rodrigo Ruano

Research output: Contribution to journalArticle

Abstract

Objectives: To investigate the perinatal outcomes of fetuses with antenatal diagnoses of intra-abdominal umbilical vein varix (UVV). Methods: A multicenter retrospective study was conducted in four countries on fetuses diagnosed with intra-abdominal UVV between 2012 and 2019. Collected data included gestational age (GA), UVV maximum diameter at diagnosis and delivery, associated anatomical and chromosomal anomalies, birth weight, and neonatal outcomes. Results: Twenty fetuses were identified, of which 20% had associated chromosomal and/or anatomical abnormalities, most resulting in poor outcomes (either intrauterine fetal death or pregnancy termination). Mean maternal age was 34.1 ± 7.0 years, UVV was diagnosed at 26.5 ± 4.5 weeks of GA on average with a maximum diameter of 12.0 ± 4.0 mm. Mean GA at delivery was 35.4 ± 5.6 weeks. Survival rate was 85%. Conclusion: Our study shows a satisfactory outcome when intra-abdominal UVV is an isolated finding, with minimal obstetrical and perinatal consequences. The prognosis is worse when UVV is associated with other anomalies.

Original languageEnglish (US)
JournalJournal of Maternal-Fetal and Neonatal Medicine
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Umbilical Veins
Varicose Veins
Multicenter Studies
Cohort Studies
Gestational Age
Fetus
Fetal Death
Maternal Age
Prenatal Diagnosis
Birth Weight
Retrospective Studies
Pregnancy

Keywords

  • Fetal ultrasound
  • prenatal diagnosis
  • thrombosis
  • umbilical vein

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Perinatal outcomes of fetal intra-abdominal umbilical vein varix : a multicenter cohort study. / Novoa, Victoria; Shazly, Sherif; Ibirogba, Eniola R.; Sutton, Laura; Tonni, Gabriele; Prefumo, Federico; Sepulveda, Waldo; Araujo Júnior, Edward; Werner, Heron; Trinidad, Mari Charisse; Ruano, Rodrigo.

In: Journal of Maternal-Fetal and Neonatal Medicine, 01.01.2019.

Research output: Contribution to journalArticle

Novoa, V, Shazly, S, Ibirogba, ER, Sutton, L, Tonni, G, Prefumo, F, Sepulveda, W, Araujo Júnior, E, Werner, H, Trinidad, MC & Ruano, R 2019, 'Perinatal outcomes of fetal intra-abdominal umbilical vein varix: a multicenter cohort study', Journal of Maternal-Fetal and Neonatal Medicine. https://doi.org/10.1080/14767058.2019.1685969
Novoa, Victoria ; Shazly, Sherif ; Ibirogba, Eniola R. ; Sutton, Laura ; Tonni, Gabriele ; Prefumo, Federico ; Sepulveda, Waldo ; Araujo Júnior, Edward ; Werner, Heron ; Trinidad, Mari Charisse ; Ruano, Rodrigo. / Perinatal outcomes of fetal intra-abdominal umbilical vein varix : a multicenter cohort study. In: Journal of Maternal-Fetal and Neonatal Medicine. 2019.
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