Perils and pitfalls of small negative clinical trials

G. Richard Locke; Alan R. Zinsmeister

doi:10.1111/j.1572-0241.2006.00527.x

Perils and pitfalls of small negative clinical trials

G. Richard Locke, Alan R. Zinsmeister

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In summary, we have tried to illustrate the perils and pitfalls of small negative clinical trials. They do not show that two treatments are different but they do not prove they are the same either. They prove little. Our goal in the long run has to be to do fewer of them. Why should a patient enroll in a study which cannot give a meaningful result? The burden is on all of us to cooperate and perform larger more definitive studies.

Original language	English (US)
Pages (from-to)	2185-2186
Number of pages	2
Journal	American Journal of Gastroenterology
Volume	101
Issue number	10
DOIs	https://doi.org/10.1111/j.1572-0241.2006.00527.x
State	Published - Oct 2006

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1111/j.1572-0241.2006.00527.x

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abstract = "In summary, we have tried to illustrate the perils and pitfalls of small negative clinical trials. They do not show that two treatments are different but they do not prove they are the same either. They prove little. Our goal in the long run has to be to do fewer of them. Why should a patient enroll in a study which cannot give a meaningful result? The burden is on all of us to cooperate and perform larger more definitive studies.",

author = "Locke, {G. Richard} and Zinsmeister, {Alan R.}",

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AB - In summary, we have tried to illustrate the perils and pitfalls of small negative clinical trials. They do not show that two treatments are different but they do not prove they are the same either. They prove little. Our goal in the long run has to be to do fewer of them. Why should a patient enroll in a study which cannot give a meaningful result? The burden is on all of us to cooperate and perform larger more definitive studies.

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Perils and pitfalls of small negative clinical trials

Abstract

ASJC Scopus subject areas

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