Pericytes in the liver

Enis Kostallari, Vijay H. Shah

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Liver pericytes, commonly named hepatic stellate cells (HSCs), reside in the space between liver sinusoidal endothelial cells (LSECs) and hepatocytes. They display important roles in health and disease. HSCs ensure the storage of the majority of vitamin A in a healthy body, and they represent the major source of fibrotic tissue in liver disease. Surrounding cells, such as LSECs, hepatocytes, and Kupffer cells, present a significant role in modulating HSC behavior. Therapeutic strategies against liver disease are being currently developed, where HSCs represent an ideal target. In this chapter, we will discuss HSC quiescence and activation in the context of healthy liver and diseases, such as fibrosis, steatohepatitis, and hepatocellular carcinoma.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages153-167
Number of pages15
DOIs
StatePublished - Jan 1 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1122
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • Fibrosis
  • Healthy liver
  • Hepatic stellate cells
  • Hepatocellular carcinoma
  • Hepatocytes
  • Kupffer cells
  • Liver
  • NAFLD
  • NASH
  • Pericytes
  • Regeneration
  • Sinusoidal endothelial cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kostallari, E., & Shah, V. H. (2019). Pericytes in the liver. In Advances in Experimental Medicine and Biology (pp. 153-167). (Advances in Experimental Medicine and Biology; Vol. 1122). Springer New York LLC. https://doi.org/10.1007/978-3-030-11093-2_9