Perianal Crohn's disease findings other than fistulas in a population-based cohort

Laurent Peyrin-Biroulet, Edward Vincent Loftus, Jr, William J. Tremaine, W. Scott Harmsen, Alan R. Zinsmeister, William J. Sandborn

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The cumulative incidence of and risk factors for perianal Crohn's disease (CD) for findings other than fistulas are unknown. Methods: The medical records of 310 incident cases of CD from Olmsted County, Minnesota, diagnosed between 1970 and 2004, were reviewed for evidence of perianal disease findings other than fistulas. Cumulative incidence was estimated using the Kaplan-Meier method, and associations between baseline factors and time to first event were assessed using proportional hazards regression. Four types of lesions were studied: anorectal strictures, deep anal canal ulcers, anal fissures, and perianal skin tags. Results: The 10-year cumulative probability from time of diagnosis was 5.8% (95% confidence interval [CI], 2.6%-8.8%) for anorectal strictures, 6.6% (3.6%-9.6%) for deep anal canal ulcers, 10.5% (6.8%-14.1%) for anal fissures, and 18.7% (13.9%-23.3%) for perianal skin tags. The cumulative probability for any perianal lesion other than fistulas was 21.3% (16.5%-25.8%) at 5 years and 29.2% (23.5%-34.5%) at 10 years. Baseline factors associated with time to first perianal lesion other than fistulas were age (hazard ratio [HR] per 10 years, 0.9; 95% CI, 0.8-0.98; P = 0.026), female gender (HR, 1.7; 95% CI, 1.1-2.7; P = 0.013), and presence of extraintestinal manifestations (HR, 1.7; 95% CI, 1.03-2.8; P = 0.038). Conclusions: Perianal lesions other than fistulas occurred frequently during the clinical course of CD. Female gender and extraintestinal manifestations were associated with increased risks for perianal lesions other than fistulas, while older age at diagnosis was associated with a slightly decreased risk.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalInflammatory Bowel Diseases
Volume18
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Crohn Disease
Fissure in Ano
Fistula
Confidence Intervals
Population
Anal Canal
Pathologic Constriction
Skin
Incidence
Medical Records

Keywords

  • anal fissures
  • anal ulcers
  • anorectal strictures
  • Crohn's disease
  • natural history
  • perianal tags

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Peyrin-Biroulet, L., Loftus, Jr, E. V., Tremaine, W. J., Harmsen, W. S., Zinsmeister, A. R., & Sandborn, W. J. (2012). Perianal Crohn's disease findings other than fistulas in a population-based cohort. Inflammatory Bowel Diseases, 18(1), 43-48. https://doi.org/10.1002/ibd.21674

Perianal Crohn's disease findings other than fistulas in a population-based cohort. / Peyrin-Biroulet, Laurent; Loftus, Jr, Edward Vincent; Tremaine, William J.; Harmsen, W. Scott; Zinsmeister, Alan R.; Sandborn, William J.

In: Inflammatory Bowel Diseases, Vol. 18, No. 1, 01.2012, p. 43-48.

Research output: Contribution to journalArticle

Peyrin-Biroulet, L, Loftus, Jr, EV, Tremaine, WJ, Harmsen, WS, Zinsmeister, AR & Sandborn, WJ 2012, 'Perianal Crohn's disease findings other than fistulas in a population-based cohort', Inflammatory Bowel Diseases, vol. 18, no. 1, pp. 43-48. https://doi.org/10.1002/ibd.21674
Peyrin-Biroulet, Laurent ; Loftus, Jr, Edward Vincent ; Tremaine, William J. ; Harmsen, W. Scott ; Zinsmeister, Alan R. ; Sandborn, William J. / Perianal Crohn's disease findings other than fistulas in a population-based cohort. In: Inflammatory Bowel Diseases. 2012 ; Vol. 18, No. 1. pp. 43-48.
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abstract = "Background: The cumulative incidence of and risk factors for perianal Crohn's disease (CD) for findings other than fistulas are unknown. Methods: The medical records of 310 incident cases of CD from Olmsted County, Minnesota, diagnosed between 1970 and 2004, were reviewed for evidence of perianal disease findings other than fistulas. Cumulative incidence was estimated using the Kaplan-Meier method, and associations between baseline factors and time to first event were assessed using proportional hazards regression. Four types of lesions were studied: anorectal strictures, deep anal canal ulcers, anal fissures, and perianal skin tags. Results: The 10-year cumulative probability from time of diagnosis was 5.8{\%} (95{\%} confidence interval [CI], 2.6{\%}-8.8{\%}) for anorectal strictures, 6.6{\%} (3.6{\%}-9.6{\%}) for deep anal canal ulcers, 10.5{\%} (6.8{\%}-14.1{\%}) for anal fissures, and 18.7{\%} (13.9{\%}-23.3{\%}) for perianal skin tags. The cumulative probability for any perianal lesion other than fistulas was 21.3{\%} (16.5{\%}-25.8{\%}) at 5 years and 29.2{\%} (23.5{\%}-34.5{\%}) at 10 years. Baseline factors associated with time to first perianal lesion other than fistulas were age (hazard ratio [HR] per 10 years, 0.9; 95{\%} CI, 0.8-0.98; P = 0.026), female gender (HR, 1.7; 95{\%} CI, 1.1-2.7; P = 0.013), and presence of extraintestinal manifestations (HR, 1.7; 95{\%} CI, 1.03-2.8; P = 0.038). Conclusions: Perianal lesions other than fistulas occurred frequently during the clinical course of CD. Female gender and extraintestinal manifestations were associated with increased risks for perianal lesions other than fistulas, while older age at diagnosis was associated with a slightly decreased risk.",
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N2 - Background: The cumulative incidence of and risk factors for perianal Crohn's disease (CD) for findings other than fistulas are unknown. Methods: The medical records of 310 incident cases of CD from Olmsted County, Minnesota, diagnosed between 1970 and 2004, were reviewed for evidence of perianal disease findings other than fistulas. Cumulative incidence was estimated using the Kaplan-Meier method, and associations between baseline factors and time to first event were assessed using proportional hazards regression. Four types of lesions were studied: anorectal strictures, deep anal canal ulcers, anal fissures, and perianal skin tags. Results: The 10-year cumulative probability from time of diagnosis was 5.8% (95% confidence interval [CI], 2.6%-8.8%) for anorectal strictures, 6.6% (3.6%-9.6%) for deep anal canal ulcers, 10.5% (6.8%-14.1%) for anal fissures, and 18.7% (13.9%-23.3%) for perianal skin tags. The cumulative probability for any perianal lesion other than fistulas was 21.3% (16.5%-25.8%) at 5 years and 29.2% (23.5%-34.5%) at 10 years. Baseline factors associated with time to first perianal lesion other than fistulas were age (hazard ratio [HR] per 10 years, 0.9; 95% CI, 0.8-0.98; P = 0.026), female gender (HR, 1.7; 95% CI, 1.1-2.7; P = 0.013), and presence of extraintestinal manifestations (HR, 1.7; 95% CI, 1.03-2.8; P = 0.038). Conclusions: Perianal lesions other than fistulas occurred frequently during the clinical course of CD. Female gender and extraintestinal manifestations were associated with increased risks for perianal lesions other than fistulas, while older age at diagnosis was associated with a slightly decreased risk.

AB - Background: The cumulative incidence of and risk factors for perianal Crohn's disease (CD) for findings other than fistulas are unknown. Methods: The medical records of 310 incident cases of CD from Olmsted County, Minnesota, diagnosed between 1970 and 2004, were reviewed for evidence of perianal disease findings other than fistulas. Cumulative incidence was estimated using the Kaplan-Meier method, and associations between baseline factors and time to first event were assessed using proportional hazards regression. Four types of lesions were studied: anorectal strictures, deep anal canal ulcers, anal fissures, and perianal skin tags. Results: The 10-year cumulative probability from time of diagnosis was 5.8% (95% confidence interval [CI], 2.6%-8.8%) for anorectal strictures, 6.6% (3.6%-9.6%) for deep anal canal ulcers, 10.5% (6.8%-14.1%) for anal fissures, and 18.7% (13.9%-23.3%) for perianal skin tags. The cumulative probability for any perianal lesion other than fistulas was 21.3% (16.5%-25.8%) at 5 years and 29.2% (23.5%-34.5%) at 10 years. Baseline factors associated with time to first perianal lesion other than fistulas were age (hazard ratio [HR] per 10 years, 0.9; 95% CI, 0.8-0.98; P = 0.026), female gender (HR, 1.7; 95% CI, 1.1-2.7; P = 0.013), and presence of extraintestinal manifestations (HR, 1.7; 95% CI, 1.03-2.8; P = 0.038). Conclusions: Perianal lesions other than fistulas occurred frequently during the clinical course of CD. Female gender and extraintestinal manifestations were associated with increased risks for perianal lesions other than fistulas, while older age at diagnosis was associated with a slightly decreased risk.

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