Performance of magnetic resonance elastography in primary sclerosing cholangitis

John E. Eaton, Bogdan Dzyubak, Sudhakar K Venkatesh, Thomas Christopher Smyrk, Gregory James Gores, Richard Lorne Ehman, Nicholas F La Russo, Andrea A. Gossard, Konstantinos N Lazaridis

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Background and Aim:: Liver stiffness (LS) measured by magnetic resonance elastography (MRE) is emerging as an important biomarker in chronic liver diseases. We examined the diagnostic performance of MRE, factors associated with an increased LS and the prognostic value of LS as measured by MRE among patients with primary sclerosing cholangitis (PSC). Methods:: We performed a retrospective review of 266 patients with PSC to examine whether LS was associated with the primary endpoint of hepatic decompensation (ascites, variceal hemorrhage and hepatic encephalopathy). The ability of MRE to differentiate stages of fibrosis was examined in a subset of patients who underwent a liver biopsy (n=20). Results:: An LS of 4.93kPa was the optimal point to detected F4 fibrosis (sensitivity, 1.00; 95% confidence interval (CI), 0.40-1.00; specificity, 0.94; 95%CI, 0.68-1.00). While a serum alkaline phosphatase 6.0kPa (respectively). Conclusion:: Magnetic resonance elastography is able to detect cirrhosis with high specificity and an alkaline phosphatase

Original languageEnglish (US)
Pages (from-to)1184-1190
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume31
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • Liver stiffness
  • Magnetic resonance elastography
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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