Performance of Atrial Fibrillation Detection in a New Single-Chamber ICD

Abhishek Deshmukh, Mark L. Brown, Elise Higgins, Brian Schousek, Athula Abeyratne, Giovanni Rovaris, Paul Andrew Friedman

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background: Patients with implantable cardioverter defibrillators (ICDs) often have a history of atrial fibrillation (AF) or will develop AF after device implant. Optimal management of ICD patients includes early diagnosis of AF and monitoring of AF burden. We evaluated the performance of an algorithm for monitoring AF in single-chamber ICDs. Methods: The RR interval variability-based detection algorithm determines RR variability by creating a Lorenz plot of the change in RR intervals for the most recent interval pair versus the previous interval pair. A new plot is created every 2 minutes and the AF evidence score of the plot is computed. Patient RR interval data from several Holter databases were pooled to test the performance of the AF detection algorithm. Results: In total, 187 recordings from 186 patients were used to assess the performance of the AF detection algorithm integrated into a single-chamber ICD by comparing the ICD detection results to the Holter annotated truth. Thirty-five of 186 patients had a total of 94 AF episodes in their Holter recordings lasting a total of 250.5 hours (mean episode duration 7.2 hours). The generalized estimating equations-adjusted estimate of episode sensitivity was 94.8% with 95% lower confidence limit of 87.2%. Gross duration sensitivity was 95.0% for AF episodes of at least 6 minutes duration with gross duration specificity of 99.6%. Conclusion: This RR interval-based AF detection algorithm performs well with high sensitivity and specificity. Integration of this algorithm into single-chamber ICDs will help monitor and detect AF, thus facilitating optimal therapy to prevent AF-related sequelae.

Original languageEnglish (US)
Pages (from-to)1031-1037
Number of pages7
JournalPACE - Pacing and Clinical Electrophysiology
Volume39
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • algorithm
  • atrial fibrillation
  • single-chamber ICD

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Performance of Atrial Fibrillation Detection in a New Single-Chamber ICD'. Together they form a unique fingerprint.

  • Cite this

    Deshmukh, A., Brown, M. L., Higgins, E., Schousek, B., Abeyratne, A., Rovaris, G., & Friedman, P. A. (2016). Performance of Atrial Fibrillation Detection in a New Single-Chamber ICD. PACE - Pacing and Clinical Electrophysiology, 39(10), 1031-1037. https://doi.org/10.1111/pace.12918