Performance characteristics of scintigraphic transit measurements for studies of experimental therapies

F. Cremonini, B. P. Mullan, Michael Camilleri, D. D. Burton, M. R. Rank

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Background: The intra- and inter-individual reproducibility of gastrointestinal and colonic transit tests require full characterization. Aims: (i) To characterize the normal values and reproducibility effects of age and gender on the scintigraphic transit of solids in health. (ii) To compare scintigraphic and radio-opaque marker measurements of colonic transit. (iii) To estimate demonstrable effect sizes for different transit end-points based on observed variations. Methods: A scintigraphic gastrointestinal and colonic transit study and the mean colonic transit time were measured using radio-opaque markers in 37 healthy volunteers; 21 subjects had a repeat scintigraphic test 3 weeks later. Results: Gastric emptying at 4 h was highly reproducible (coefficient of variation, 4%) on repeat testing. The colonic measurement varied by more than I geometric centre unit in 37% of subjects at 24 h and in 26% of subjects at 48 h. There were no age- or gender-related differences in transit. Effect sizes demonstrable with 14 subjects per group were in the range previously shown to be clinically relevant: 25% change in gastric emptying at 4 h; 1.5 geometric centre unit change in colonic transit at 48 h. Conclusions: These data demonstrate the reproducibility and performance to be expected of transit measurements and are essential for designing studies in experimental therapeutics.

Original languageEnglish (US)
Pages (from-to)1781-1790
Number of pages10
JournalAlimentary Pharmacology and Therapeutics
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2002

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Gastrointestinal Transit
Investigational Therapies
Gastric Emptying
Healthy Volunteers
Reference Values
Health
Radio-Opaque acrylic resin
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Performance characteristics of scintigraphic transit measurements for studies of experimental therapies. / Cremonini, F.; Mullan, B. P.; Camilleri, Michael; Burton, D. D.; Rank, M. R.

In: Alimentary Pharmacology and Therapeutics, Vol. 16, No. 10, 01.10.2002, p. 1781-1790.

Research output: Contribution to journalArticle

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