Percutaneous renal cryoablation after partial nephrectomy: Technical feasibility, complications and outcomes

Ryan M. Hegg, Grant D. Schmit, Stephen A. Boorjian, Robert McDonald, A. Nicholas Kurup, Adam J. Weisbrod, Matthew R Callstrom, Thomas D. Atwell, R. Houston Thompson

Research output: Contribution to journalArticle

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Abstract

Purpose: Treatment of locally recurrent or de novo tumors in the ipsilateral kidney after partial nephrectomy represents a management dilemma. Percutaneous renal cryoablation offers a minimally invasive treatment option in such cases. We review our single institution experience with percutaneous cryoablation of renal tumors after partial nephrectomy for technical feasibility, complications and outcomes. Materials and Methods: Between March 2003 and January 2012, 48 patients underwent percutaneous cryoablation for the treatment of 68 ipsilateral renal tumors after previous partial nephrectomy. Oncologic outcomes, complications (Clavien-Dindo classification system) and renal function were evaluated. Results: Median maximal diameter of the treated renal tumors was 2.5 cm (range 1.2 to 5.4). All cryoablation procedures were considered technically successful. Of the 54 biopsy proven or suspected renal cell carcinomas with 3 or more months of computerized tomography/magnetic resonance imaging followup after cryoablation (median 19, range 3 to 61), 5 cases (9.3%) had local tumor recurrence. Major (grade 3 or greater) complications developed after 3 (5.7%) cryoablation procedures and there were no perioperative deaths. Median change in patient estimated glomerular filtration rate after renal cryoablation was -1.5 ml per minute. No patients required dialysis in the perioperative period, while 2 with stage 4 chronic kidney disease at the time of ablation became dialysis dependent at 5 and 23 months after treatment, respectively. Conclusions: Percutaneous renal cryoablation after ipsilateral partial nephrectomy is technically feasible, has a low rate of major complications, provides relative preservation of renal function and demonstrates acceptable short-term oncologic outcomes in this challenging population.

Original languageEnglish (US)
Pages (from-to)1243-1248
Number of pages6
JournalJournal of Urology
Volume189
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Cryosurgery
Nephrectomy
Kidney
Neoplasms
Dialysis
Perioperative Period
Therapeutics
Glomerular Filtration Rate
Chronic Renal Insufficiency
Renal Cell Carcinoma
Tomography
Magnetic Resonance Imaging
Biopsy
Recurrence

Keywords

  • ablation techniques
  • kidney
  • outcome assessment
  • treatment outcome

ASJC Scopus subject areas

  • Urology

Cite this

Hegg, R. M., Schmit, G. D., Boorjian, S. A., McDonald, R., Kurup, A. N., Weisbrod, A. J., ... Thompson, R. H. (2013). Percutaneous renal cryoablation after partial nephrectomy: Technical feasibility, complications and outcomes. Journal of Urology, 189(4), 1243-1248. https://doi.org/10.1016/j.juro.2012.10.066

Percutaneous renal cryoablation after partial nephrectomy : Technical feasibility, complications and outcomes. / Hegg, Ryan M.; Schmit, Grant D.; Boorjian, Stephen A.; McDonald, Robert; Kurup, A. Nicholas; Weisbrod, Adam J.; Callstrom, Matthew R; Atwell, Thomas D.; Thompson, R. Houston.

In: Journal of Urology, Vol. 189, No. 4, 04.2013, p. 1243-1248.

Research output: Contribution to journalArticle

Hegg, RM, Schmit, GD, Boorjian, SA, McDonald, R, Kurup, AN, Weisbrod, AJ, Callstrom, MR, Atwell, TD & Thompson, RH 2013, 'Percutaneous renal cryoablation after partial nephrectomy: Technical feasibility, complications and outcomes', Journal of Urology, vol. 189, no. 4, pp. 1243-1248. https://doi.org/10.1016/j.juro.2012.10.066
Hegg, Ryan M. ; Schmit, Grant D. ; Boorjian, Stephen A. ; McDonald, Robert ; Kurup, A. Nicholas ; Weisbrod, Adam J. ; Callstrom, Matthew R ; Atwell, Thomas D. ; Thompson, R. Houston. / Percutaneous renal cryoablation after partial nephrectomy : Technical feasibility, complications and outcomes. In: Journal of Urology. 2013 ; Vol. 189, No. 4. pp. 1243-1248.
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