Peptidergic Edinger-Westphal neurons and the energy-dependent stress response

Lu Xu, Wim J.J.M. Scheenen, Eric W. Roubos, Tamas Kozicz

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The continuously changing environment demands for adequate stress responses to maintain the internal dynamic equilibrium of body and mind. A successful stress response requires energy, in an amount matching the severity of the stressor and the type of response ('fight, flight or freeze'). The stress response is generated by the central nervous system, which needs to be informed about both the threatening stressor and the availability of energy. In this review, evidence is considered for a role of the midbrain Edinger-Westphal centrally projecting neuron population (EWcp; synonym: non-preganglionic Edinger-Westphal nucleus) in the energy-dependent stress adaptation response. It deals with studies on the neurochemical organization of the EWcp with particular reference to the neuropeptides urocortin-1 and cocaine- and amphetamine-regulated transcript peptide, on the EWcp responses to different types of stressor (e.g., acute and chronic) and a changed energy state (e.g., fasting and leptin change), and on the sex-specificity of these responses. Finally, a model is presented for the way the EWcp might contribute to the coordination of the energy-dependent stress adaptation response.

Original languageEnglish (US)
Pages (from-to)296-304
Number of pages9
JournalGeneral and Comparative Endocrinology
Volume177
Issue number3
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

Fingerprint

Urocortins
Amphetamine
Mesencephalon
Leptin
Neuropeptides
Cocaine
Fasting
stress response
Central Nervous System
neurons
Neurons
Peptides
energy
Population
amphetamine
cocaine
neuropeptides
leptin
central nervous system
fasting

Keywords

  • Adipose tissue
  • Cocaine- and amphetamine-related transcript peptide
  • Depression
  • Energy metabolism
  • Feeding
  • Gender differences
  • Leptin
  • Nesfatin-1
  • Obesity
  • Urocortin-1

ASJC Scopus subject areas

  • Endocrinology

Cite this

Peptidergic Edinger-Westphal neurons and the energy-dependent stress response. / Xu, Lu; Scheenen, Wim J.J.M.; Roubos, Eric W.; Kozicz, Tamas.

In: General and Comparative Endocrinology, Vol. 177, No. 3, 01.07.2012, p. 296-304.

Research output: Contribution to journalReview article

Xu, Lu ; Scheenen, Wim J.J.M. ; Roubos, Eric W. ; Kozicz, Tamas. / Peptidergic Edinger-Westphal neurons and the energy-dependent stress response. In: General and Comparative Endocrinology. 2012 ; Vol. 177, No. 3. pp. 296-304.
@article{ddaadf2823f7466db094928ae9591a90,
title = "Peptidergic Edinger-Westphal neurons and the energy-dependent stress response",
abstract = "The continuously changing environment demands for adequate stress responses to maintain the internal dynamic equilibrium of body and mind. A successful stress response requires energy, in an amount matching the severity of the stressor and the type of response ('fight, flight or freeze'). The stress response is generated by the central nervous system, which needs to be informed about both the threatening stressor and the availability of energy. In this review, evidence is considered for a role of the midbrain Edinger-Westphal centrally projecting neuron population (EWcp; synonym: non-preganglionic Edinger-Westphal nucleus) in the energy-dependent stress adaptation response. It deals with studies on the neurochemical organization of the EWcp with particular reference to the neuropeptides urocortin-1 and cocaine- and amphetamine-regulated transcript peptide, on the EWcp responses to different types of stressor (e.g., acute and chronic) and a changed energy state (e.g., fasting and leptin change), and on the sex-specificity of these responses. Finally, a model is presented for the way the EWcp might contribute to the coordination of the energy-dependent stress adaptation response.",
keywords = "Adipose tissue, Cocaine- and amphetamine-related transcript peptide, Depression, Energy metabolism, Feeding, Gender differences, Leptin, Nesfatin-1, Obesity, Urocortin-1",
author = "Lu Xu and Scheenen, {Wim J.J.M.} and Roubos, {Eric W.} and Tamas Kozicz",
year = "2012",
month = "7",
day = "1",
doi = "10.1016/j.ygcen.2011.11.039",
language = "English (US)",
volume = "177",
pages = "296--304",
journal = "General and Comparative Endocrinology",
issn = "0016-6480",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Peptidergic Edinger-Westphal neurons and the energy-dependent stress response

AU - Xu, Lu

AU - Scheenen, Wim J.J.M.

AU - Roubos, Eric W.

AU - Kozicz, Tamas

PY - 2012/7/1

Y1 - 2012/7/1

N2 - The continuously changing environment demands for adequate stress responses to maintain the internal dynamic equilibrium of body and mind. A successful stress response requires energy, in an amount matching the severity of the stressor and the type of response ('fight, flight or freeze'). The stress response is generated by the central nervous system, which needs to be informed about both the threatening stressor and the availability of energy. In this review, evidence is considered for a role of the midbrain Edinger-Westphal centrally projecting neuron population (EWcp; synonym: non-preganglionic Edinger-Westphal nucleus) in the energy-dependent stress adaptation response. It deals with studies on the neurochemical organization of the EWcp with particular reference to the neuropeptides urocortin-1 and cocaine- and amphetamine-regulated transcript peptide, on the EWcp responses to different types of stressor (e.g., acute and chronic) and a changed energy state (e.g., fasting and leptin change), and on the sex-specificity of these responses. Finally, a model is presented for the way the EWcp might contribute to the coordination of the energy-dependent stress adaptation response.

AB - The continuously changing environment demands for adequate stress responses to maintain the internal dynamic equilibrium of body and mind. A successful stress response requires energy, in an amount matching the severity of the stressor and the type of response ('fight, flight or freeze'). The stress response is generated by the central nervous system, which needs to be informed about both the threatening stressor and the availability of energy. In this review, evidence is considered for a role of the midbrain Edinger-Westphal centrally projecting neuron population (EWcp; synonym: non-preganglionic Edinger-Westphal nucleus) in the energy-dependent stress adaptation response. It deals with studies on the neurochemical organization of the EWcp with particular reference to the neuropeptides urocortin-1 and cocaine- and amphetamine-regulated transcript peptide, on the EWcp responses to different types of stressor (e.g., acute and chronic) and a changed energy state (e.g., fasting and leptin change), and on the sex-specificity of these responses. Finally, a model is presented for the way the EWcp might contribute to the coordination of the energy-dependent stress adaptation response.

KW - Adipose tissue

KW - Cocaine- and amphetamine-related transcript peptide

KW - Depression

KW - Energy metabolism

KW - Feeding

KW - Gender differences

KW - Leptin

KW - Nesfatin-1

KW - Obesity

KW - Urocortin-1

UR - http://www.scopus.com/inward/record.url?scp=84862491467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862491467&partnerID=8YFLogxK

U2 - 10.1016/j.ygcen.2011.11.039

DO - 10.1016/j.ygcen.2011.11.039

M3 - Review article

C2 - 22166814

AN - SCOPUS:84862491467

VL - 177

SP - 296

EP - 304

JO - General and Comparative Endocrinology

JF - General and Comparative Endocrinology

SN - 0016-6480

IS - 3

ER -