PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)

Medicine & Life Sciences

• Tissue Inhibitor of Metalloproteinase-1 100%
• Half-Life 73%
• Tissue Inhibitor of Metalloproteinases 44%
• In Vitro Techniques 36%
• Matrix Metalloproteinases 32%
• human TIMP1 protein 30%
• Gelatinases 22%
• Neoplasms 21%
• Matrix Metalloproteinase 3 21%
• Matrix Metalloproteinase Inhibitors 20%
• Matrix Metalloproteinase 9 17%
• Biological Assay 17%
• Biological Products 16%
• Recombinant Proteins 16%
• Lysine 16%
• Catalytic Domain 15%
• Mass Spectrometry 15%
• Arthritis 14%
• Disease Progression 13%
• Pharmacokinetics 12%
• Cardiovascular Diseases 12%
• Therapeutics 10%
• Enzymes 9%

Agriculture & Biology

• metalloproteinases 93%
• half life 75%
• tissues 37%
• therapeutics 21%
• neoplasm cells 16%
• stromelysin 1 15%
• neoplasm progression 13%
• gelatinase B 13%
• disease progression 11%
• biopharmaceuticals 11%
• arthritis 11%
• cardiovascular diseases 10%
• pharmacokinetics 9%
• recombinant proteins 9%
• active sites 8%
• mass spectrometry 7%
• lysine 7%
• bioassays 7%
• neoplasms 7%
• proteinases 6%
• toxicity 6%
• mice 5%
• enzymes 4%

Chemical Compounds

• Reaction Half Life 79%
• Plasma 51%
• Lysine Residue 46%
• Pharmacokinetics 31%
• Mass Spectrometry 27%
• Length 24%
• Mixture 18%
• Protein 17%
• Molecule 14%
• Application 13%