Pediatric melanomas often mimic benign skin lesions: A retrospective study

Mario Mitkov, Marie Chrest, Nancy N. Diehl, Michael G. Heckman, Megha Tollefson, Anokhi Jambusaria-Pahlajani

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background Childhood melanoma can be misdiagnosed because of its rarity and atypical presentation. Objective We sought to correlate the clinical appearance of pediatric melanomas with Breslow depth and clinical behavior, and to identify diagnostic errors made by dermatologists and nondermatologist physicians. Methods This was a retrospective review of Mayo Clinic records of children and young adults 21 years of age or younger with a diagnosis of primary cutaneous melanoma between January 2000 and January 2015. Results Pediatric melanomas that mimicked benign skin lesions were more often deeper (>1 mm; odds ratio 5.48; P = .002) and had a higher T stage (odds ratio [T2, T3, or T4] 6.28; P = .001) than melanomas with a clinically malignant appearance. Of pediatric melanomas, 66% originally diagnosed as benign melanocytic lesions exhibited changes in size, shape, and color. Limitations Sample size and retrospective design are limitations. Conclusions Benign-appearing pediatric skin lesions with a history of evolution, bleeding, or ulceration should raise suspicion for melanoma. Melanomas demonstrating these features are associated with a higher Breslow depth and T stage. Although biopsy of all lesions that exhibit change in children is not practical, safe, or desired, close monitoring is recommended.

Original languageEnglish (US)
Pages (from-to)706-711.e4
JournalJournal of the American Academy of Dermatology
Volume75
Issue number4
DOIs
StatePublished - Oct 1 2016

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Melanoma
Retrospective Studies
Pediatrics
Skin
Diagnostic Errors
Odds Ratio
Sample Size
Young Adult
Color
Hemorrhage
Physicians
Biopsy

Keywords

  • Breslow depth
  • childhood
  • clinical appearance
  • early detection
  • melanoma
  • pediatric

ASJC Scopus subject areas

  • Dermatology

Cite this

Pediatric melanomas often mimic benign skin lesions : A retrospective study. / Mitkov, Mario; Chrest, Marie; Diehl, Nancy N.; Heckman, Michael G.; Tollefson, Megha; Jambusaria-Pahlajani, Anokhi.

In: Journal of the American Academy of Dermatology, Vol. 75, No. 4, 01.10.2016, p. 706-711.e4.

Research output: Contribution to journalArticle

Mitkov, Mario ; Chrest, Marie ; Diehl, Nancy N. ; Heckman, Michael G. ; Tollefson, Megha ; Jambusaria-Pahlajani, Anokhi. / Pediatric melanomas often mimic benign skin lesions : A retrospective study. In: Journal of the American Academy of Dermatology. 2016 ; Vol. 75, No. 4. pp. 706-711.e4.
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