Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease

Lisa J. Martin, James P. Franciosi, Margaret H. Collins, J. Pablo Abonia, James J. Lee, Kevin A. Hommel, James W. Varni, J. Tommie Grotjan, Michael Eby, Hua He, Keith Marsolo, Philip E. Putnam, Jose M. Garza, Ajay Kaul, Ting Wen, Marc E. Rothenberg

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background The Pediatric Eosinophilic Esophagitis Symptom Score (PEESS v2.0) measures patient-relevant outcomes. However, whether patient-identified domains (dysphagia, gastroesophageal reflux disease [GERD], nausea/vomiting, and pain) align with clinical symptomology and histopathologic and molecular features of eosinophilic esophagitis (EoE) is unclear. Objective The purpose of this study was to determine whether clinical features of EoE, measured through PEESS v2.0, associate with histopathologic and molecular features of EoE. This represents a novel approach for analysis of allergic diseases, given the availability of allergic tissue biopsy specimens. Methods We systematically recruited treated and untreated pediatric patients with EoE (aged 2-18 years) and examined parent proxy-reported symptoms using the PEESS v2.0. Clinical symptomology was collected by questionnaire. Esophageal biopsy samples were quantified for levels of eosinophils, eosinophil peroxidase (EPX) immunohistochemical staining, and mast cells. Molecular features were assessed by using the EoE Diagnostic Panel (94 EoE-related gene transcripts). Associations between domain scores and clinical symptoms and biological features were analyzed with Wilcoxon rank sum and Spearman correlation. Results The PEESS v2.0 domains correlated to specific parent-reported symptoms: dysphagia (P =.0012), GERD (P =.0001), and nausea/vomiting (P

Original languageEnglish (US)
Pages (from-to)1519-1528e8
JournalJournal of Allergy and Clinical Immunology
Volume135
Issue number6
DOIs
StatePublished - Jun 1 2015

Fingerprint

Eosinophilic Esophagitis
Pediatrics
Deglutition Disorders
Gastroesophageal Reflux
Nausea
Vomiting
Eosinophil Peroxidase
Biopsy
Proxy
Eosinophils
Mast Cells
Staining and Labeling
Pain

Keywords

  • Allergy
  • mast cells
  • microarray
  • molecular genetics
  • patient-reported outcomes
  • pediatrics
  • quality of life
  • reflux
  • surveys

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease. / Martin, Lisa J.; Franciosi, James P.; Collins, Margaret H.; Abonia, J. Pablo; Lee, James J.; Hommel, Kevin A.; Varni, James W.; Grotjan, J. Tommie; Eby, Michael; He, Hua; Marsolo, Keith; Putnam, Philip E.; Garza, Jose M.; Kaul, Ajay; Wen, Ting; Rothenberg, Marc E.

In: Journal of Allergy and Clinical Immunology, Vol. 135, No. 6, 01.06.2015, p. 1519-1528e8.

Research output: Contribution to journalArticle

Martin, LJ, Franciosi, JP, Collins, MH, Abonia, JP, Lee, JJ, Hommel, KA, Varni, JW, Grotjan, JT, Eby, M, He, H, Marsolo, K, Putnam, PE, Garza, JM, Kaul, A, Wen, T & Rothenberg, ME 2015, 'Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease', Journal of Allergy and Clinical Immunology, vol. 135, no. 6, pp. 1519-1528e8. https://doi.org/10.1016/j.jaci.2015.03.004
Martin, Lisa J. ; Franciosi, James P. ; Collins, Margaret H. ; Abonia, J. Pablo ; Lee, James J. ; Hommel, Kevin A. ; Varni, James W. ; Grotjan, J. Tommie ; Eby, Michael ; He, Hua ; Marsolo, Keith ; Putnam, Philip E. ; Garza, Jose M. ; Kaul, Ajay ; Wen, Ting ; Rothenberg, Marc E. / Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease. In: Journal of Allergy and Clinical Immunology. 2015 ; Vol. 135, No. 6. pp. 1519-1528e8.
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AU - Franciosi, James P.

AU - Collins, Margaret H.

AU - Abonia, J. Pablo

AU - Lee, James J.

AU - Hommel, Kevin A.

AU - Varni, James W.

AU - Grotjan, J. Tommie

AU - Eby, Michael

AU - He, Hua

AU - Marsolo, Keith

AU - Putnam, Philip E.

AU - Garza, Jose M.

AU - Kaul, Ajay

AU - Wen, Ting

AU - Rothenberg, Marc E.

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N2 - Background The Pediatric Eosinophilic Esophagitis Symptom Score (PEESS v2.0) measures patient-relevant outcomes. However, whether patient-identified domains (dysphagia, gastroesophageal reflux disease [GERD], nausea/vomiting, and pain) align with clinical symptomology and histopathologic and molecular features of eosinophilic esophagitis (EoE) is unclear. Objective The purpose of this study was to determine whether clinical features of EoE, measured through PEESS v2.0, associate with histopathologic and molecular features of EoE. This represents a novel approach for analysis of allergic diseases, given the availability of allergic tissue biopsy specimens. Methods We systematically recruited treated and untreated pediatric patients with EoE (aged 2-18 years) and examined parent proxy-reported symptoms using the PEESS v2.0. Clinical symptomology was collected by questionnaire. Esophageal biopsy samples were quantified for levels of eosinophils, eosinophil peroxidase (EPX) immunohistochemical staining, and mast cells. Molecular features were assessed by using the EoE Diagnostic Panel (94 EoE-related gene transcripts). Associations between domain scores and clinical symptoms and biological features were analyzed with Wilcoxon rank sum and Spearman correlation. Results The PEESS v2.0 domains correlated to specific parent-reported symptoms: dysphagia (P =.0012), GERD (P =.0001), and nausea/vomiting (P

AB - Background The Pediatric Eosinophilic Esophagitis Symptom Score (PEESS v2.0) measures patient-relevant outcomes. However, whether patient-identified domains (dysphagia, gastroesophageal reflux disease [GERD], nausea/vomiting, and pain) align with clinical symptomology and histopathologic and molecular features of eosinophilic esophagitis (EoE) is unclear. Objective The purpose of this study was to determine whether clinical features of EoE, measured through PEESS v2.0, associate with histopathologic and molecular features of EoE. This represents a novel approach for analysis of allergic diseases, given the availability of allergic tissue biopsy specimens. Methods We systematically recruited treated and untreated pediatric patients with EoE (aged 2-18 years) and examined parent proxy-reported symptoms using the PEESS v2.0. Clinical symptomology was collected by questionnaire. Esophageal biopsy samples were quantified for levels of eosinophils, eosinophil peroxidase (EPX) immunohistochemical staining, and mast cells. Molecular features were assessed by using the EoE Diagnostic Panel (94 EoE-related gene transcripts). Associations between domain scores and clinical symptoms and biological features were analyzed with Wilcoxon rank sum and Spearman correlation. Results The PEESS v2.0 domains correlated to specific parent-reported symptoms: dysphagia (P =.0012), GERD (P =.0001), and nausea/vomiting (P

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