PDLIM4, an actin binding protein, suppresses prostate cancer cell growth

Krishna V Donkena, Michael E. Grossmann, John C. Cheville, Mozammel H. Gazi, Aiyu Gong, Jin San Zhang, Katalin Ajtai, Thomas P. Burghardt, Charles Y.F. Young

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

We investigated the molecular function of PDLIM4 in prostate cancer cells. PDLIM4 mRNA and protein-expression levels were reduced in LNCaP, LAPC4, DU145, CWR22, and PC3 prostate cancer cells. The re-expression of PDLIM4 in prostate cancer cells has significantly reduced the cell growth and clonogenicity with G1 phase of cell-cycle arrest. We have shown the direct interaction of PDLIM4 with F-actin. Restoration of PDLIM4 expression resulted in reduction of tumor growth in xenografts. These results suggest that PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells.

Original languageEnglish (US)
Pages (from-to)264-272
Number of pages9
JournalCancer Investigation
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2009

Keywords

  • Actin cytoskeleton
  • Cell growth
  • LIM domain protein
  • Prostate cancer
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Donkena, K. V., Grossmann, M. E., Cheville, J. C., Gazi, M. H., Gong, A., Zhang, J. S., Ajtai, K., Burghardt, T. P., & Young, C. Y. F. (2009). PDLIM4, an actin binding protein, suppresses prostate cancer cell growth. Cancer Investigation, 27(3), 264-272. https://doi.org/10.1080/07357900802406319