Abstract
We investigated the molecular function of PDLIM4 in prostate cancer cells. PDLIM4 mRNA and protein-expression levels were reduced in LNCaP, LAPC4, DU145, CWR22, and PC3 prostate cancer cells. The re-expression of PDLIM4 in prostate cancer cells has significantly reduced the cell growth and clonogenicity with G1 phase of cell-cycle arrest. We have shown the direct interaction of PDLIM4 with F-actin. Restoration of PDLIM4 expression resulted in reduction of tumor growth in xenografts. These results suggest that PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells.
Original language | English (US) |
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Pages (from-to) | 264-272 |
Number of pages | 9 |
Journal | Cancer Investigation |
Volume | 27 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2009 |
Keywords
- Actin cytoskeleton
- Cell growth
- LIM domain protein
- Prostate cancer
- Tumor suppressor gene
ASJC Scopus subject areas
- Oncology
- Cancer Research