PDGFRα: A new therapeutic target in the treatment of hepatocellular carcinoma?

Abdul M. Oseini, Lewis R. Roberts

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Background: Hepatocellular carcinoma (HCC) develops most often in a background of chronic inflammatory liver injury from viral infection or alcohol use. Most HCCs are diagnosed at a stage at which surgical resection is not feasible. Even in patients receiving surgery rates of recurrence and metastasis remain high. There are few effective HCC therapies and hence a need for novel, rational approaches to treatment. Platelet derived growth factor receptor-? (PDGFR-?) is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of HCC. Objective: To examine PDGFR-α as a target for therapy of HCC and explore opportunities and strategies for PDGFR-α inhibition. Methods: A review of relevant literature. Results/conclusions: Targeted inhibition of PDGFR-α is a rational strategy for prevention and therapy of HCC.

Original languageEnglish (US)
Pages (from-to)443-454
Number of pages12
JournalExpert opinion on therapeutic targets
Volume13
Issue number4
DOIs
StatePublished - Apr 1 2009

Keywords

  • FGF
  • HCC
  • Heparinase
  • Hepatocarcinogenesis
  • PDGF
  • Receptor tyrosine kinase
  • SULF1
  • SULF2
  • VEGF

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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