@article{47e9e3d422844583aa47692ea12e22fd,
title = "PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy",
abstract = "Tu et al. demonstrated that intracellular PD-L1 regulates the DNA damage response by binding and stabilizing the mRNAs of DNA damage genes. Furthermore, a novel PD-L1 antibody, H1A, can sensitize cancer to DNA-damaging therapy by promoting PD-L1 degradation.",
keywords = "CMTM6, DNA repair, PD-L1, PD-L1 destabilization, RNA binding, RNA exosome, anti-B7-H1 antibody, chemotherapy, immunotherapy, radiotherapy",
author = "Xinyi Tu and Bo Qin and Yong Zhang and Cheng Zhang and Mohamed Kahila and Somaira Nowsheen and Ping Yin and Jian Yuan and Huadong Pei and Hu Li and Jia Yu and Zhiwang Song and Qin Zhou and Fei Zhao and Jiaqi Liu and Chao Zhang and Haidong Dong and Mutter, {Robert W.} and Zhenkun Lou",
note = "Funding Information: This work was supported in part by the American Society for Radiation Oncology and the National Cancer Institute of the NIH under award numbers CA203561 , P50CA116201 , and K12 HD065987 ; HALT Cancer at X ; NCI R21 CA197878 (to H.D.); the National Institute of Allergy and Infectious Diseases (NIAID) R01 AI095239 ; and The Mayo Clinic Center for Biomedical Discovery (CBD) for support of our production of antibody. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = jun,
day = "20",
doi = "10.1016/j.molcel.2019.04.005",
language = "English (US)",
volume = "74",
pages = "1215--1226.e4",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "6",
}