PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Xinyi Tu, Bo Qin, Yong Zhang, Cheng Zhang, Mohamed Kahila, Somaira Nowsheen, Ping Yin, Jian Yuan, Huadong Pei, Hu Li, Jia Yu, Zhiwang Song, Qin Zhou, Fei Zhao, Jiaqi Liu, Chao Zhang, Haidong M Dong, Robert Mutter, Zhenkun Lou

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Tu et al. demonstrated that intracellular PD-L1 regulates the DNA damage response by binding and stabilizing the mRNAs of DNA damage genes. Furthermore, a novel PD-L1 antibody, H1A, can sensitize cancer to DNA-damaging therapy by promoting PD-L1 degradation.

Original languageEnglish (US)
Pages (from-to)1215-1226.e4
JournalMolecular Cell
Volume74
Issue number6
DOIs
StatePublished - Jun 20 2019

Fingerprint

Exosome Multienzyme Ribonuclease Complex
DNA Damage
Radiation
Drug Therapy
Genetic Therapy
Messenger RNA
Antibodies
Genes
Neoplasms

Keywords

  • anti-B7-H1 antibody
  • chemotherapy
  • CMTM6
  • DNA repair
  • immunotherapy
  • PD-L1
  • PD-L1 destabilization
  • radiotherapy
  • RNA binding
  • RNA exosome

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy. / Tu, Xinyi; Qin, Bo; Zhang, Yong; Zhang, Cheng; Kahila, Mohamed; Nowsheen, Somaira; Yin, Ping; Yuan, Jian; Pei, Huadong; Li, Hu; Yu, Jia; Song, Zhiwang; Zhou, Qin; Zhao, Fei; Liu, Jiaqi; Zhang, Chao; Dong, Haidong M; Mutter, Robert; Lou, Zhenkun.

In: Molecular Cell, Vol. 74, No. 6, 20.06.2019, p. 1215-1226.e4.

Research output: Contribution to journalArticle

Tu, X, Qin, B, Zhang, Y, Zhang, C, Kahila, M, Nowsheen, S, Yin, P, Yuan, J, Pei, H, Li, H, Yu, J, Song, Z, Zhou, Q, Zhao, F, Liu, J, Zhang, C, Dong, HM, Mutter, R & Lou, Z 2019, 'PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy', Molecular Cell, vol. 74, no. 6, pp. 1215-1226.e4. https://doi.org/10.1016/j.molcel.2019.04.005
Tu, Xinyi ; Qin, Bo ; Zhang, Yong ; Zhang, Cheng ; Kahila, Mohamed ; Nowsheen, Somaira ; Yin, Ping ; Yuan, Jian ; Pei, Huadong ; Li, Hu ; Yu, Jia ; Song, Zhiwang ; Zhou, Qin ; Zhao, Fei ; Liu, Jiaqi ; Zhang, Chao ; Dong, Haidong M ; Mutter, Robert ; Lou, Zhenkun. / PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy. In: Molecular Cell. 2019 ; Vol. 74, No. 6. pp. 1215-1226.e4.
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abstract = "Tu et al. demonstrated that intracellular PD-L1 regulates the DNA damage response by binding and stabilizing the mRNAs of DNA damage genes. Furthermore, a novel PD-L1 antibody, H1A, can sensitize cancer to DNA-damaging therapy by promoting PD-L1 degradation.",
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