Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer

Joshua G. Barton, Thomas Schnelldorfer, Christine M. Lohse, William R. Bamlet, Kari G. Rabe, Gloria M Petersen, John H. Donohue, Michael B. Farnell, Michael L. Kendrick, David M. Nagorney, Kay M Reid Lombardo, Florencia Que

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well. Aims: This study aims to evaluate outcomes following resection in patients with familial PC. Methods: We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients. Results: Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52). Conclusions: Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.

Original languageEnglish (US)
Pages (from-to)836-842
Number of pages7
JournalJournal of Gastrointestinal Surgery
Volume15
Issue number5
DOIs
StatePublished - May 2011

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Pancreatic Neoplasms
Pancreas
Neoplasms
Bilirubin
Weight Loss
Demography

Keywords

  • Familial cancer syndrome
  • Familial pancreatic cancer
  • Pancreatic cancer

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer. / Barton, Joshua G.; Schnelldorfer, Thomas; Lohse, Christine M.; Bamlet, William R.; Rabe, Kari G.; Petersen, Gloria M; Donohue, John H.; Farnell, Michael B.; Kendrick, Michael L.; Nagorney, David M.; Lombardo, Kay M Reid; Que, Florencia.

In: Journal of Gastrointestinal Surgery, Vol. 15, No. 5, 05.2011, p. 836-842.

Research output: Contribution to journalArticle

Barton, JG, Schnelldorfer, T, Lohse, CM, Bamlet, WR, Rabe, KG, Petersen, GM, Donohue, JH, Farnell, MB, Kendrick, ML, Nagorney, DM, Lombardo, KMR & Que, F 2011, 'Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer', Journal of Gastrointestinal Surgery, vol. 15, no. 5, pp. 836-842. https://doi.org/10.1007/s11605-011-1417-x
Barton, Joshua G. ; Schnelldorfer, Thomas ; Lohse, Christine M. ; Bamlet, William R. ; Rabe, Kari G. ; Petersen, Gloria M ; Donohue, John H. ; Farnell, Michael B. ; Kendrick, Michael L. ; Nagorney, David M. ; Lombardo, Kay M Reid ; Que, Florencia. / Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer. In: Journal of Gastrointestinal Surgery. 2011 ; Vol. 15, No. 5. pp. 836-842.
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AU - Barton, Joshua G.

AU - Schnelldorfer, Thomas

AU - Lohse, Christine M.

AU - Bamlet, William R.

AU - Rabe, Kari G.

AU - Petersen, Gloria M

AU - Donohue, John H.

AU - Farnell, Michael B.

AU - Kendrick, Michael L.

AU - Nagorney, David M.

AU - Lombardo, Kay M Reid

AU - Que, Florencia

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AB - Background: Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well. Aims: This study aims to evaluate outcomes following resection in patients with familial PC. Methods: We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients. Results: Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52). Conclusions: Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.

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