Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer

Joshua G. Barton; Thomas Schnelldorfer; Christine M. Lohse; William R. Bamlet; Kari G. Rabe; Gloria M. Petersen; John H. Donohue; Michael B. Farnell; Michael L. Kendrick; David M. Nagorney; Kay M.Reid Lombardo; Florencia G. Que

doi:10.1007/s11605-011-1417-x

Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer

Joshua G. Barton, Thomas Schnelldorfer, Christine M. Lohse, William R. Bamlet, Kari G. Rabe, Gloria M. Petersen, John H. Donohue, Michael B. Farnell, Michael L. Kendrick, David M. Nagorney, Kay M.Reid Lombardo, Florencia G. Que

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Abstract

Background: Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well. Aims: This study aims to evaluate outcomes following resection in patients with familial PC. Methods: We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients. Results: Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52). Conclusions: Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.

Original language	English (US)
Pages (from-to)	836-842
Number of pages	7
Journal	Journal of Gastrointestinal Surgery
Volume	15
Issue number	5
DOIs	https://doi.org/10.1007/s11605-011-1417-x
State	Published - May 2011

Keywords

Familial cancer syndrome
Familial pancreatic cancer
Pancreatic cancer

ASJC Scopus subject areas

Surgery
Gastroenterology

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10.1007/s11605-011-1417-x

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Barton, J. G., Schnelldorfer, T., Lohse, C. M., Bamlet, W. R., Rabe, K. G., Petersen, G. M., Donohue, J. H., Farnell, M. B., Kendrick, M. L., Nagorney, D. M., Lombardo, K. M. R., & Que, F. G. (2011). Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer. Journal of Gastrointestinal Surgery, 15(5), 836-842. https://doi.org/10.1007/s11605-011-1417-x

Barton, JG, Schnelldorfer, T, Lohse, CM, Bamlet, WR, Rabe, KG, Petersen, GM, Donohue, JH, Farnell, MB, Kendrick, ML, Nagorney, DM, Lombardo, KMR & Que, FG 2011, 'Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer', Journal of Gastrointestinal Surgery, vol. 15, no. 5, pp. 836-842. https://doi.org/10.1007/s11605-011-1417-x

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title = "Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer",

abstract = "Background: Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well. Aims: This study aims to evaluate outcomes following resection in patients with familial PC. Methods: We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients. Results: Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52). Conclusions: Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.",

keywords = "Familial cancer syndrome, Familial pancreatic cancer, Pancreatic cancer",

author = "Barton, {Joshua G.} and Thomas Schnelldorfer and Lohse, {Christine M.} and Bamlet, {William R.} and Rabe, {Kari G.} and Petersen, {Gloria M.} and Donohue, {John H.} and Farnell, {Michael B.} and Kendrick, {Michael L.} and Nagorney, {David M.} and Lombardo, {Kay M.Reid} and Que, {Florencia G.}",

note = "Funding Information: The Biospecimen Resource for Pancreas Research at our institution, supported by the Specialized Program of Research Excellence (SPORE) in Pancreatic Cancer (NCI P50CA102701), prospectively registered 326 patients who underwent resection of various pancreatic lesions from October 2000 to June 2007. Both the SPORE in pancreatic cancer and this study obtained full institutional review board approval at our institution prior to initiating the investigation. A final study sample was comprised of 234 patients who underwent resection of pancreatic ductal adenocarcinoma and had completed family history questionnaires in conjunction with registration into the Biospecimen Resource for Pancreas Research. Of these 234 patients, 208 had typical ductal adenocarcinoma and 26 had IPMN-invasive carcinoma. The group of 208 patients with typical ductal adenocarcinoma was the primary focus of this study (Fig. 1). We compared demographics, pre-operative clinical variables, surgical variables, staging, and outcomes of patients with",

year = "2011",

month = may,

doi = "10.1007/s11605-011-1417-x",

language = "English (US)",

volume = "15",

pages = "836--842",

journal = "Journal of Gastrointestinal Surgery",

issn = "1091-255X",

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TY - JOUR

T1 - Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer

AU - Barton, Joshua G.

AU - Schnelldorfer, Thomas

AU - Lohse, Christine M.

AU - Bamlet, William R.

AU - Rabe, Kari G.

AU - Petersen, Gloria M.

AU - Donohue, John H.

AU - Farnell, Michael B.

AU - Kendrick, Michael L.

AU - Nagorney, David M.

AU - Lombardo, Kay M.Reid

AU - Que, Florencia G.

N1 - Funding Information: The Biospecimen Resource for Pancreas Research at our institution, supported by the Specialized Program of Research Excellence (SPORE) in Pancreatic Cancer (NCI P50CA102701), prospectively registered 326 patients who underwent resection of various pancreatic lesions from October 2000 to June 2007. Both the SPORE in pancreatic cancer and this study obtained full institutional review board approval at our institution prior to initiating the investigation. A final study sample was comprised of 234 patients who underwent resection of pancreatic ductal adenocarcinoma and had completed family history questionnaires in conjunction with registration into the Biospecimen Resource for Pancreas Research. Of these 234 patients, 208 had typical ductal adenocarcinoma and 26 had IPMN-invasive carcinoma. The group of 208 patients with typical ductal adenocarcinoma was the primary focus of this study (Fig. 1). We compared demographics, pre-operative clinical variables, surgical variables, staging, and outcomes of patients with

PY - 2011/5

Y1 - 2011/5

N2 - Background: Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well. Aims: This study aims to evaluate outcomes following resection in patients with familial PC. Methods: We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients. Results: Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52). Conclusions: Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.

AB - Background: Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well. Aims: This study aims to evaluate outcomes following resection in patients with familial PC. Methods: We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients. Results: Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52). Conclusions: Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.

KW - Familial cancer syndrome

KW - Familial pancreatic cancer

KW - Pancreatic cancer

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AN - SCOPUS:79955469080

SN - 1091-255X

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JO - Journal of Gastrointestinal Surgery

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Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer

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