Patterns of failure following the excision of in-transit lesions in melanoma and the influence of excisional margins

Alexandra B. Gonzalez, Christian L. Baum, Jerry D. Brewer, Christopher J. Arpey, William S. Harmsen, Vera J. Suman, Svetomir N. Markovic, James W. Jakub

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background and Objectives: To describe the patterns of failure in patients with in-transit (IT) melanoma undergoing surgical excision. Methods: A retrospective review of patients who underwent their first IT lesion(s) resection between May 2005 and September 2014. Cumulative incidence of local failure (new lesion within 2 cm of IT resection) was estimated. Associations between clinicopathologic characteristics, local failure, and any recurrence were analyzed. Results: One hundred and thirty patients presented to our institution with IT disease over the study period and met the inclusion criteria. The 2-year cumulative incidence of local failure was 19.5%. Twenty-four patients developed disease within 2 cm of the resected IT disease; however, only eight were isolated local events. Cumulative incidence of local failure and of any disease differed with respect to less than 1 year disease-free interval (DFI) from primary melanoma to first IT event, and having greater than 1 IT lesion at presentation. Incidence of local failure was not found to differ with respect to gross margin greater than 5 mm, after adjusting for DFI and greater than 1 IT lesions. Conclusions: Patients with greater than 1 IT lesion and a DFI less than 1 year are at a higher risk of failure after surgical excision of a first IT event. Very few failures were isolated local disease within 2 cm of the IT resection scar, regardless of IT excision margin.

Original languageEnglish (US)
Pages (from-to)606-613
Number of pages8
JournalJournal of Surgical Oncology
Volume118
Issue number4
DOIs
StatePublished - Sep 15 2018

Keywords

  • disease-free interval
  • in-transit melanoma
  • local recurrence
  • satellites
  • stage III

ASJC Scopus subject areas

  • Surgery
  • Oncology

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