Patterns of care and survival outcomes after treatment for uveal melanoma in the post-coms era (2004-2013): A surveillance, epidemiology, and end results analysis

Yuan James Rao, Julia Sein, Shahed Badiyan, Julie K. Schwarz, Todd DeWees, Perry Grigsby, Prabakar Kumar Rao

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: The Collaborative Ocular Melanoma Study (COMS) established modern treatment recommendations for uveal melanoma. We aim to evaluate patterns of care and survival outcomes in the time after COMS. Material and methods: The retrospective study population includes 2,611 patients in the SEER database treated for uveal melanoma between 2004-2013. Patients stage were T1-4N0M0. Data analyzed included age, clinical stage, tumor size, race, and treatment. Treatments included enucleation (EN) and globe preserving therapy (GPT), which consisted of limited surgical resection or ablation (LSRA), external beam radiation (EBRT), or brachytherapy (BT). Patients treated with radiation may receive radiation therapy alone (RTA) or radiation therapy and supplemental laser therapy (RT+SLT). We evaluated disease specific survival (DSS) and overall survival (OS) using log-rank statistics, and Cox univariate and multivariate analysis. Results: The median follow-up was 44 months. Treatment strategy was EN in 538 (20.6%) patients, LSRA in 80 (3.1%), EBRT in 609 (23.3%), and BT in 1,384 (53.0%). 1,876 patients received RTA and 117 received RT+SLT. Enucleation was associated with inferior DSS and OS compared to GPT in multivariate analysis (MVA) (p < 0.01). Limited surgical resection or ablation and radiation had similar DSS and OS. Brachytherapy and EBRT had similar DSS and OS. Radiation therapy and supplemental laser therapy was associated with improved DSS compared to RTA in UVA (p = 0.03), but not MVA. The 5-year DSS for enucleation, RTA, and RT+SLT were 66.7%, 87.0%, and 94.7% (p < 0.01), respectively. Conclusions: Globe preserving treatments such as limited surgery or radiation are commonly utilized alternatives to enucleation, and resulted in favorable survival outcomes. Additional research is required to compare the outcomes of the various globe preserving treatment strategies.

Original languageEnglish (US)
Pages (from-to)453-465
Number of pages13
JournalJournal of Contemporary Brachytherapy
Volume9
Issue number5
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Epidemiology
Survival
Radiotherapy
Radiation
Brachytherapy
Multivariate Analysis
Laser Therapy
Therapeutics
Uveal melanoma
Melanoma
Retrospective Studies
Databases
Research

Keywords

  • Brachytherapy
  • Enucleation
  • Epidemiology and end results (SEER)
  • Laser
  • Transpupillary thermotherapy (TTT)
  • Uveal melanoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Patterns of care and survival outcomes after treatment for uveal melanoma in the post-coms era (2004-2013) : A surveillance, epidemiology, and end results analysis. / Rao, Yuan James; Sein, Julia; Badiyan, Shahed; Schwarz, Julie K.; DeWees, Todd; Grigsby, Perry; Rao, Prabakar Kumar.

In: Journal of Contemporary Brachytherapy, Vol. 9, No. 5, 01.01.2017, p. 453-465.

Research output: Contribution to journalArticle

Rao, Yuan James ; Sein, Julia ; Badiyan, Shahed ; Schwarz, Julie K. ; DeWees, Todd ; Grigsby, Perry ; Rao, Prabakar Kumar. / Patterns of care and survival outcomes after treatment for uveal melanoma in the post-coms era (2004-2013) : A surveillance, epidemiology, and end results analysis. In: Journal of Contemporary Brachytherapy. 2017 ; Vol. 9, No. 5. pp. 453-465.
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abstract = "Purpose: The Collaborative Ocular Melanoma Study (COMS) established modern treatment recommendations for uveal melanoma. We aim to evaluate patterns of care and survival outcomes in the time after COMS. Material and methods: The retrospective study population includes 2,611 patients in the SEER database treated for uveal melanoma between 2004-2013. Patients stage were T1-4N0M0. Data analyzed included age, clinical stage, tumor size, race, and treatment. Treatments included enucleation (EN) and globe preserving therapy (GPT), which consisted of limited surgical resection or ablation (LSRA), external beam radiation (EBRT), or brachytherapy (BT). Patients treated with radiation may receive radiation therapy alone (RTA) or radiation therapy and supplemental laser therapy (RT+SLT). We evaluated disease specific survival (DSS) and overall survival (OS) using log-rank statistics, and Cox univariate and multivariate analysis. Results: The median follow-up was 44 months. Treatment strategy was EN in 538 (20.6{\%}) patients, LSRA in 80 (3.1{\%}), EBRT in 609 (23.3{\%}), and BT in 1,384 (53.0{\%}). 1,876 patients received RTA and 117 received RT+SLT. Enucleation was associated with inferior DSS and OS compared to GPT in multivariate analysis (MVA) (p < 0.01). Limited surgical resection or ablation and radiation had similar DSS and OS. Brachytherapy and EBRT had similar DSS and OS. Radiation therapy and supplemental laser therapy was associated with improved DSS compared to RTA in UVA (p = 0.03), but not MVA. The 5-year DSS for enucleation, RTA, and RT+SLT were 66.7{\%}, 87.0{\%}, and 94.7{\%} (p < 0.01), respectively. Conclusions: Globe preserving treatments such as limited surgery or radiation are commonly utilized alternatives to enucleation, and resulted in favorable survival outcomes. Additional research is required to compare the outcomes of the various globe preserving treatment strategies.",
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AU - Badiyan, Shahed

AU - Schwarz, Julie K.

AU - DeWees, Todd

AU - Grigsby, Perry

AU - Rao, Prabakar Kumar

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N2 - Purpose: The Collaborative Ocular Melanoma Study (COMS) established modern treatment recommendations for uveal melanoma. We aim to evaluate patterns of care and survival outcomes in the time after COMS. Material and methods: The retrospective study population includes 2,611 patients in the SEER database treated for uveal melanoma between 2004-2013. Patients stage were T1-4N0M0. Data analyzed included age, clinical stage, tumor size, race, and treatment. Treatments included enucleation (EN) and globe preserving therapy (GPT), which consisted of limited surgical resection or ablation (LSRA), external beam radiation (EBRT), or brachytherapy (BT). Patients treated with radiation may receive radiation therapy alone (RTA) or radiation therapy and supplemental laser therapy (RT+SLT). We evaluated disease specific survival (DSS) and overall survival (OS) using log-rank statistics, and Cox univariate and multivariate analysis. Results: The median follow-up was 44 months. Treatment strategy was EN in 538 (20.6%) patients, LSRA in 80 (3.1%), EBRT in 609 (23.3%), and BT in 1,384 (53.0%). 1,876 patients received RTA and 117 received RT+SLT. Enucleation was associated with inferior DSS and OS compared to GPT in multivariate analysis (MVA) (p < 0.01). Limited surgical resection or ablation and radiation had similar DSS and OS. Brachytherapy and EBRT had similar DSS and OS. Radiation therapy and supplemental laser therapy was associated with improved DSS compared to RTA in UVA (p = 0.03), but not MVA. The 5-year DSS for enucleation, RTA, and RT+SLT were 66.7%, 87.0%, and 94.7% (p < 0.01), respectively. Conclusions: Globe preserving treatments such as limited surgery or radiation are commonly utilized alternatives to enucleation, and resulted in favorable survival outcomes. Additional research is required to compare the outcomes of the various globe preserving treatment strategies.

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KW - Enucleation

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KW - Laser

KW - Transpupillary thermotherapy (TTT)

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