TY - JOUR
T1 - Pattern of regional white matter hyperintensity volume in mild cognitive impairment subtypes and associations with decline in daily functioning
AU - Alzheimer’s Disease Neuroimaging Initiative
AU - Bangen, Katherine J.
AU - Thomas, Kelsey R.
AU - Weigand, Alexandra J.
AU - Sanchez, Danielle L.
AU - Delano-Wood, Lisa
AU - Edmonds, Emily C.
AU - Carmichael, Owen T.
AU - Schwarz, Christopher G.
AU - Brickman, Adam M.
AU - Bondi, Mark W.
N1 - Publisher Copyright:
© 2019
PY - 2020/2
Y1 - 2020/2
N2 - White matter hyperintensities (WMHs), a marker of small-vessel cerebrovascular disease, increase risk for mild cognitive impairment (MCI). Less is known about whether regional WMHs distinguish MCI subtypes and predict decline in everyday functioning. About 618 Alzheimer's Disease Neuroimaging Initiative participants (301 cognitively normal [CN]; 232 amnestic MCI [aMCI]; 85 nonamnestic MCI [naMCI]) underwent neuropsychological testing, MRI, and assessment of everyday functioning. aMCI participants showed greater temporal (p = 0.002) and occipital WMHs (p = 0.030) relative to CN whereas naMCI participants had greater frontal (p = 0.045), temporal (p = 0.003), parietal (p = 0.018), and occipital (p < 0.001) WMH compared with CN. Relative to those with aMCI, individuals with naMCI showed greater occipital WMH (p = 0.013). Greater WMH in temporal (p = 0.001) and occipital regions (p = 0.006) was associated with faster decline in everyday functioning across the sample. Temporal lobe WMHs were disproportionately associated with accelerated functional decline among naMCI (p = 0.045). Regional WMH volumes vary across cognitive groups and predict functional decline. Cerebrovascular markers may help identify individuals at risk for decline and distinguish subtypes of cognitive impairment.
AB - White matter hyperintensities (WMHs), a marker of small-vessel cerebrovascular disease, increase risk for mild cognitive impairment (MCI). Less is known about whether regional WMHs distinguish MCI subtypes and predict decline in everyday functioning. About 618 Alzheimer's Disease Neuroimaging Initiative participants (301 cognitively normal [CN]; 232 amnestic MCI [aMCI]; 85 nonamnestic MCI [naMCI]) underwent neuropsychological testing, MRI, and assessment of everyday functioning. aMCI participants showed greater temporal (p = 0.002) and occipital WMHs (p = 0.030) relative to CN whereas naMCI participants had greater frontal (p = 0.045), temporal (p = 0.003), parietal (p = 0.018), and occipital (p < 0.001) WMH compared with CN. Relative to those with aMCI, individuals with naMCI showed greater occipital WMH (p = 0.013). Greater WMH in temporal (p = 0.001) and occipital regions (p = 0.006) was associated with faster decline in everyday functioning across the sample. Temporal lobe WMHs were disproportionately associated with accelerated functional decline among naMCI (p = 0.045). Regional WMH volumes vary across cognitive groups and predict functional decline. Cerebrovascular markers may help identify individuals at risk for decline and distinguish subtypes of cognitive impairment.
KW - Cerebrovascular disease
KW - Daily functioning
KW - MCI subtypes
KW - Mild cognitive impairment
KW - Neuropsychology
KW - White matter hyperintensity
UR - http://www.scopus.com/inward/record.url?scp=85076233492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076233492&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2019.10.016
DO - 10.1016/j.neurobiolaging.2019.10.016
M3 - Article
C2 - 31791658
AN - SCOPUS:85076233492
SN - 0197-4580
VL - 86
SP - 134
EP - 142
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -