Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies

Zuzana Nedelska; Tanis J. Ferman; Bradley F. Boeve; Scott A. Przybelski; Timothy G. Lesnick; Melissa E. Murray; Jeffrey L. Gunter; Matthew L. Senjem; Prashanti Vemuri; Glenn E. Smith; Yonas E. Geda; Jonathan Graff-Radford; David S. Knopman; Ronald C. Petersen; Joseph E. Parisi; Dennis W. Dickson; Clifford R. Jack; Kejal Kantarci

doi:10.1016/j.neurobiolaging.2014.07.005

Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies

Zuzana Nedelska, Tanis J. Ferman, Bradley F. Boeve, Scott A. Przybelski, Timothy G. Lesnick, Melissa E. Murray, Jeffrey L. Gunter, Matthew L. Senjem, Prashanti Vemuri, Glenn E. Smith, Yonas E. Geda, Jonathan Graff-Radford, David S. Knopman, Ronald C. Petersen, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack, Kejal Kantarci

Research output: Contribution to journal › Article › peer-review

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Abstract

Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We investigated the pattern and magnitude of the atrophy rates from 2 serial MRIs in autopsy-confirmed DLB patients (n = 20) and mixed DLB/AD patients (n = 22), compared with AD (n = 30) and elderly nondemented control subjects (n = 15), followed antemortem. DLB patients without significant AD-type pathology were characterized by lower global and regional rates of atrophy, similar to control subjects. The mixed DLB/AD patients displayed greater atrophy rates in the whole brain, temporoparietal cortices, hippocampus and amygdala, and ventricle expansion, similar to AD patients. In the DLB and DLB/AD patients, the atrophy rates correlated with Braak neurofibrillary tangle stage, cognitive decline, and progression of motor symptoms. Global and regional atrophy rates are associated with AD-type pathology in DLB, and these rates can be used as biomarkers of AD progression in patients with LB pathology.

Original language	English (US)
Pages (from-to)	452-461
Number of pages	10
Journal	Neurobiology of aging
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.07.005
State	Published - Jan 1 2015

Keywords

Alzheimer's disease
Atrophy rate
Autopsy-confirmed dementia with Lewy bodies
Braak neurofibrillary tangle stage
Sample size estimate
Serial MRI

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2014.07.005

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Nedelska, Z., Ferman, T. J., Boeve, B. F., Przybelski, S. A., Lesnick, T. G., Murray, M. E., Gunter, J. L., Senjem, M. L., Vemuri, P., Smith, G. E., Geda, Y. E., Graff-Radford, J., Knopman, D. S., Petersen, R. C., Parisi, J. E., Dickson, D. W., Jack, C. R., & Kantarci, K. (2015). Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. Neurobiology of aging, 36(1), 452-461. https://doi.org/10.1016/j.neurobiolaging.2014.07.005

Nedelska, Z, Ferman, TJ , Boeve, BF, Przybelski, SA, Lesnick, TG, Murray, ME, Gunter, JL, Senjem, ML, Vemuri, P, Smith, GE, Geda, YE, Graff-Radford, J , Knopman, DS , Petersen, RC, Parisi, JE, Dickson, DW , Jack, CR & Kantarci, K 2015, 'Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies', Neurobiology of aging, vol. 36, no. 1, pp. 452-461. https://doi.org/10.1016/j.neurobiolaging.2014.07.005

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title = "Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies",

abstract = "Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We investigated the pattern and magnitude of the atrophy rates from 2 serial MRIs in autopsy-confirmed DLB patients (n = 20) and mixed DLB/AD patients (n = 22), compared with AD (n = 30) and elderly nondemented control subjects (n = 15), followed antemortem. DLB patients without significant AD-type pathology were characterized by lower global and regional rates of atrophy, similar to control subjects. The mixed DLB/AD patients displayed greater atrophy rates in the whole brain, temporoparietal cortices, hippocampus and amygdala, and ventricle expansion, similar to AD patients. In the DLB and DLB/AD patients, the atrophy rates correlated with Braak neurofibrillary tangle stage, cognitive decline, and progression of motor symptoms. Global and regional atrophy rates are associated with AD-type pathology in DLB, and these rates can be used as biomarkers of AD progression in patients with LB pathology.",

keywords = "Alzheimer's disease, Atrophy rate, Autopsy-confirmed dementia with Lewy bodies, Braak neurofibrillary tangle stage, Sample size estimate, Serial MRI",

author = "Zuzana Nedelska and Ferman, {Tanis J.} and Boeve, {Bradley F.} and Przybelski, {Scott A.} and Lesnick, {Timothy G.} and Murray, {Melissa E.} and Gunter, {Jeffrey L.} and Senjem, {Matthew L.} and Prashanti Vemuri and Smith, {Glenn E.} and Geda, {Yonas E.} and Jonathan Graff-Radford and Knopman, {David S.} and Petersen, {Ronald C.} and Parisi, {Joseph E.} and Dickson, {Dennis W.} and Jack, {Clifford R.} and Kejal Kantarci",

note = "Funding Information: The study was funded by the National Institutes of Health P50-AG16574/P1 and R01AG040042 (to Kejal Kantarci), R01-AG015866 (to Tanis J. Ferman), R01-AG11378 (to Clifford R. Jack), and P50-AG16574 (to Ronald C. Petersen), Mangurian Foundation , and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program. Zuzana Nedelska is supported by the CTSA grant number UL1 TR000135 from the National Center for Advancing Translational Sciences, United States , a component of the NIH (its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH), Grant Agency of Charles University in Prague (doctoral student grant 624012 ), and European Regional Development Fund–Project FNUSA-ICRC CZ.1.05/1.1.00/02.0123, European Social Fund within the project Young Talent Incubator II (reg. CZ.1.07/2.3.00/20.0117) and the State Budget of the Czech Republic . Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

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doi = "10.1016/j.neurobiolaging.2014.07.005",

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AU - Nedelska, Zuzana

AU - Ferman, Tanis J.

AU - Boeve, Bradley F.

AU - Przybelski, Scott A.

AU - Lesnick, Timothy G.

AU - Murray, Melissa E.

AU - Gunter, Jeffrey L.

AU - Senjem, Matthew L.

AU - Vemuri, Prashanti

AU - Smith, Glenn E.

AU - Geda, Yonas E.

AU - Graff-Radford, Jonathan

AU - Knopman, David S.

AU - Petersen, Ronald C.

AU - Parisi, Joseph E.

AU - Dickson, Dennis W.

AU - Jack, Clifford R.

AU - Kantarci, Kejal

N1 - Funding Information: The study was funded by the National Institutes of Health P50-AG16574/P1 and R01AG040042 (to Kejal Kantarci), R01-AG015866 (to Tanis J. Ferman), R01-AG11378 (to Clifford R. Jack), and P50-AG16574 (to Ronald C. Petersen), Mangurian Foundation , and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program. Zuzana Nedelska is supported by the CTSA grant number UL1 TR000135 from the National Center for Advancing Translational Sciences, United States , a component of the NIH (its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH), Grant Agency of Charles University in Prague (doctoral student grant 624012 ), and European Regional Development Fund–Project FNUSA-ICRC CZ.1.05/1.1.00/02.0123, European Social Fund within the project Young Talent Incubator II (reg. CZ.1.07/2.3.00/20.0117) and the State Budget of the Czech Republic . Publisher Copyright: © 2015 Elsevier Inc.

PY - 2015/1/1

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N2 - Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We investigated the pattern and magnitude of the atrophy rates from 2 serial MRIs in autopsy-confirmed DLB patients (n = 20) and mixed DLB/AD patients (n = 22), compared with AD (n = 30) and elderly nondemented control subjects (n = 15), followed antemortem. DLB patients without significant AD-type pathology were characterized by lower global and regional rates of atrophy, similar to control subjects. The mixed DLB/AD patients displayed greater atrophy rates in the whole brain, temporoparietal cortices, hippocampus and amygdala, and ventricle expansion, similar to AD patients. In the DLB and DLB/AD patients, the atrophy rates correlated with Braak neurofibrillary tangle stage, cognitive decline, and progression of motor symptoms. Global and regional atrophy rates are associated with AD-type pathology in DLB, and these rates can be used as biomarkers of AD progression in patients with LB pathology.

AB - Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We investigated the pattern and magnitude of the atrophy rates from 2 serial MRIs in autopsy-confirmed DLB patients (n = 20) and mixed DLB/AD patients (n = 22), compared with AD (n = 30) and elderly nondemented control subjects (n = 15), followed antemortem. DLB patients without significant AD-type pathology were characterized by lower global and regional rates of atrophy, similar to control subjects. The mixed DLB/AD patients displayed greater atrophy rates in the whole brain, temporoparietal cortices, hippocampus and amygdala, and ventricle expansion, similar to AD patients. In the DLB and DLB/AD patients, the atrophy rates correlated with Braak neurofibrillary tangle stage, cognitive decline, and progression of motor symptoms. Global and regional atrophy rates are associated with AD-type pathology in DLB, and these rates can be used as biomarkers of AD progression in patients with LB pathology.

KW - Alzheimer's disease

KW - Atrophy rate

KW - Autopsy-confirmed dementia with Lewy bodies

KW - Braak neurofibrillary tangle stage

KW - Sample size estimate

KW - Serial MRI

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Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies

Abstract

Keywords

ASJC Scopus subject areas

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