Abstract
Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We investigated the pattern and magnitude of the atrophy rates from 2 serial MRIs in autopsy-confirmed DLB patients (n = 20) and mixed DLB/AD patients (n = 22), compared with AD (n = 30) and elderly nondemented control subjects (n = 15), followed antemortem. DLB patients without significant AD-type pathology were characterized by lower global and regional rates of atrophy, similar to control subjects. The mixed DLB/AD patients displayed greater atrophy rates in the whole brain, temporoparietal cortices, hippocampus and amygdala, and ventricle expansion, similar to AD patients. In the DLB and DLB/AD patients, the atrophy rates correlated with Braak neurofibrillary tangle stage, cognitive decline, and progression of motor symptoms. Global and regional atrophy rates are associated with AD-type pathology in DLB, and these rates can be used as biomarkers of AD progression in patients with LB pathology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 452-461 |
| Number of pages | 10 |
| Journal | Neurobiology of Aging |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2015 |
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Keywords
- Alzheimer's disease
- Atrophy rate
- Autopsy-confirmed dementia with Lewy bodies
- Braak neurofibrillary tangle stage
- Sample size estimate
- Serial MRI
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
- Aging
- Developmental Biology
- Geriatrics and Gerontology
Cite this
Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. / Nedelska, Zuzana; Ferman, Tanis Jill; Boeve, Bradley F; Przybelski, Scott A.; Lesnick, Timothy G.; Murray, Melissa E; Gunter, Jeffrey L.; Senjem, Matthew L.; Vemuri, Prashanthi D; Smith, Glenn E.; Geda, Yonas Endale; Graff-Radford, Jonathan; Knopman, David S; Petersen, Ronald Carl; Parisi, Joseph E; Dickson, Dennis W; Jack, Clifford R Jr.; Kantarci, Kejal M.
In: Neurobiology of Aging, Vol. 36, No. 1, 01.01.2015, p. 452-461.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies
AU - Nedelska, Zuzana
AU - Ferman, Tanis Jill
AU - Boeve, Bradley F
AU - Przybelski, Scott A.
AU - Lesnick, Timothy G.
AU - Murray, Melissa E
AU - Gunter, Jeffrey L.
AU - Senjem, Matthew L.
AU - Vemuri, Prashanthi D
AU - Smith, Glenn E.
AU - Geda, Yonas Endale
AU - Graff-Radford, Jonathan
AU - Knopman, David S
AU - Petersen, Ronald Carl
AU - Parisi, Joseph E
AU - Dickson, Dennis W
AU - Jack, Clifford R Jr.
AU - Kantarci, Kejal M
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We investigated the pattern and magnitude of the atrophy rates from 2 serial MRIs in autopsy-confirmed DLB patients (n = 20) and mixed DLB/AD patients (n = 22), compared with AD (n = 30) and elderly nondemented control subjects (n = 15), followed antemortem. DLB patients without significant AD-type pathology were characterized by lower global and regional rates of atrophy, similar to control subjects. The mixed DLB/AD patients displayed greater atrophy rates in the whole brain, temporoparietal cortices, hippocampus and amygdala, and ventricle expansion, similar to AD patients. In the DLB and DLB/AD patients, the atrophy rates correlated with Braak neurofibrillary tangle stage, cognitive decline, and progression of motor symptoms. Global and regional atrophy rates are associated with AD-type pathology in DLB, and these rates can be used as biomarkers of AD progression in patients with LB pathology.
AB - Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We investigated the pattern and magnitude of the atrophy rates from 2 serial MRIs in autopsy-confirmed DLB patients (n = 20) and mixed DLB/AD patients (n = 22), compared with AD (n = 30) and elderly nondemented control subjects (n = 15), followed antemortem. DLB patients without significant AD-type pathology were characterized by lower global and regional rates of atrophy, similar to control subjects. The mixed DLB/AD patients displayed greater atrophy rates in the whole brain, temporoparietal cortices, hippocampus and amygdala, and ventricle expansion, similar to AD patients. In the DLB and DLB/AD patients, the atrophy rates correlated with Braak neurofibrillary tangle stage, cognitive decline, and progression of motor symptoms. Global and regional atrophy rates are associated with AD-type pathology in DLB, and these rates can be used as biomarkers of AD progression in patients with LB pathology.
KW - Alzheimer's disease
KW - Atrophy rate
KW - Autopsy-confirmed dementia with Lewy bodies
KW - Braak neurofibrillary tangle stage
KW - Sample size estimate
KW - Serial MRI
UR - http://www.scopus.com/inward/record.url?scp=84920624841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920624841&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2014.07.005
DO - 10.1016/j.neurobiolaging.2014.07.005
M3 - Article
C2 - 25128280
AN - SCOPUS:84920624841
VL - 36
SP - 452
EP - 461
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 1
ER -