Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies

Zuzana Nedelska; Tanis J. Ferman; Bradley F. Boeve; Scott A. Przybelski; Timothy G. Lesnick; Melissa E. Murray; Jeffrey L. Gunter; Matthew L. Senjem; Prashanti Vemuri; Glenn E. Smith; Yonas E. Geda; Jonathan Graff-Radford; David S. Knopman; Ronald C. Petersen; Joseph E. Parisi; Dennis W. Dickson; Clifford R. Jack; Kejal Kantarci

doi:10.1016/j.neurobiolaging.2014.07.005

Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies

Zuzana Nedelska, Tanis J. Ferman, Bradley F. Boeve, Scott A. Przybelski, Timothy G. Lesnick, Melissa E. Murray, Jeffrey L. Gunter, Matthew L. Senjem, Prashanti Vemuri, Glenn E. Smith, Yonas E. Geda, Jonathan Graff-Radford, David S. Knopman, Ronald C. Petersen, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack, Kejal Kantarci

Research output: Contribution to journal › Article

68 Scopus citations

Abstract

Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We investigated the pattern and magnitude of the atrophy rates from 2 serial MRIs in autopsy-confirmed DLB patients (n = 20) and mixed DLB/AD patients (n = 22), compared with AD (n = 30) and elderly nondemented control subjects (n = 15), followed antemortem. DLB patients without significant AD-type pathology were characterized by lower global and regional rates of atrophy, similar to control subjects. The mixed DLB/AD patients displayed greater atrophy rates in the whole brain, temporoparietal cortices, hippocampus and amygdala, and ventricle expansion, similar to AD patients. In the DLB and DLB/AD patients, the atrophy rates correlated with Braak neurofibrillary tangle stage, cognitive decline, and progression of motor symptoms. Global and regional atrophy rates are associated with AD-type pathology in DLB, and these rates can be used as biomarkers of AD progression in patients with LB pathology.

Original language	English (US)
Pages (from-to)	452-461
Number of pages	10
Journal	Neurobiology of aging
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.07.005
State	Published - Jan 1 2015

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Keywords

Alzheimer's disease
Atrophy rate
Autopsy-confirmed dementia with Lewy bodies
Braak neurofibrillary tangle stage
Sample size estimate
Serial MRI

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

Cite this

Nedelska, Z., Ferman, T. J., Boeve, B. F., Przybelski, S. A., Lesnick, T. G., Murray, M. E., Gunter, J. L., Senjem, M. L., Vemuri, P., Smith, G. E., Geda, Y. E., Graff-Radford, J., Knopman, D. S., Petersen, R. C., Parisi, J. E., Dickson, D. W., Jack, C. R., & Kantarci, K. (2015). Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. Neurobiology of aging, 36(1), 452-461. https://doi.org/10.1016/j.neurobiolaging.2014.07.005

Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. / Nedelska, Zuzana; Ferman, Tanis J.; Boeve, Bradley F.; Przybelski, Scott A.; Lesnick, Timothy G.; Murray, Melissa E.; Gunter, Jeffrey L.; Senjem, Matthew L.; Vemuri, Prashanti; Smith, Glenn E.; Geda, Yonas E.; Graff-Radford, Jonathan ; Knopman, David S.; Petersen, Ronald C.; Parisi, Joseph E.; Dickson, Dennis W.; Jack, Clifford R.; Kantarci, Kejal.

In: Neurobiology of aging, Vol. 36, No. 1, 01.01.2015, p. 452-461.

Research output: Contribution to journal › Article

Nedelska, Z, Ferman, TJ , Boeve, BF, Przybelski, SA, Lesnick, TG, Murray, ME, Gunter, JL, Senjem, ML, Vemuri, P, Smith, GE, Geda, YE , Graff-Radford, J , Knopman, DS , Petersen, RC, Parisi, JE, Dickson, DW , Jack, CR & Kantarci, K 2015, 'Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies', Neurobiology of aging, vol. 36, no. 1, pp. 452-461. https://doi.org/10.1016/j.neurobiolaging.2014.07.005

Nedelska, Zuzana ; Ferman, Tanis J. ; Boeve, Bradley F. ; Przybelski, Scott A. ; Lesnick, Timothy G. ; Murray, Melissa E. ; Gunter, Jeffrey L. ; Senjem, Matthew L. ; Vemuri, Prashanti ; Smith, Glenn E. ; Geda, Yonas E. ; Graff-Radford, Jonathan ; Knopman, David S. ; Petersen, Ronald C. ; Parisi, Joseph E. ; Dickson, Dennis W. ; Jack, Clifford R. ; Kantarci, Kejal. / Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. In: Neurobiology of aging. 2015 ; Vol. 36, No. 1. pp. 452-461.

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10.1016/j.neurobiolaging.2014.07.005