Patients with giant cell arteritis have a lower prevalence of diabetes mellitus: A systematic review and meta-analysis

Patompong Ungprasert, Sikarin Upala, Anawin Sanguankeo, Kenneth J Warrington

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The aim of this study is to compare the prevalence of diabetes mellitus (DM) in patients who are recently diagnosed with giant cell arteritis (GCA) with age- and sex-matched controls. Methods: We conducted a systematic review and meta-analysis of observational studies that (1) consisted of GCA cohort and non-GCA cohort that was randomly selected from the same population and (2) provided prevalences of DM at the time of diagnosis for patients with GCA and at the index date for controls. Pooled odds ratios and 95% confidence intervals (CIs) were calculated using a random-effect, Mantel–Haenszel analysis. Results: Five studies with 903 patients with GCA and 1064 controls were identified and included in our data analysis. We demonstrated a statistically significant lower prevalence of DM among patients with GCA with the pooled OR of 0.74 (95% CI, 0.57–0.97). Conclusion: At diagnosis, patients with GCA had a lower prevalence of DM. Whether DM could be a protective factor against the development of GCA needs further investigations.

Original languageEnglish (US)
JournalModern Rheumatology
DOIs
StateAccepted/In press - Sep 17 2015

Fingerprint

Giant Cell Arteritis
Meta-Analysis
Diabetes Mellitus
Confidence Intervals
Arteritis
Observational Studies
Odds Ratio
Population

Keywords

  • Epidemiology
  • Giant cell arteritis
  • Meta-analysis
  • Systematic review
  • Temporal arteritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Patients with giant cell arteritis have a lower prevalence of diabetes mellitus : A systematic review and meta-analysis. / Ungprasert, Patompong; Upala, Sikarin; Sanguankeo, Anawin; Warrington, Kenneth J.

In: Modern Rheumatology, 17.09.2015.

Research output: Contribution to journalArticle

@article{eb873e27863c4cfb8b22a0fe68bedf6c,
title = "Patients with giant cell arteritis have a lower prevalence of diabetes mellitus: A systematic review and meta-analysis",
abstract = "Objective: The aim of this study is to compare the prevalence of diabetes mellitus (DM) in patients who are recently diagnosed with giant cell arteritis (GCA) with age- and sex-matched controls. Methods: We conducted a systematic review and meta-analysis of observational studies that (1) consisted of GCA cohort and non-GCA cohort that was randomly selected from the same population and (2) provided prevalences of DM at the time of diagnosis for patients with GCA and at the index date for controls. Pooled odds ratios and 95{\%} confidence intervals (CIs) were calculated using a random-effect, Mantel–Haenszel analysis. Results: Five studies with 903 patients with GCA and 1064 controls were identified and included in our data analysis. We demonstrated a statistically significant lower prevalence of DM among patients with GCA with the pooled OR of 0.74 (95{\%} CI, 0.57–0.97). Conclusion: At diagnosis, patients with GCA had a lower prevalence of DM. Whether DM could be a protective factor against the development of GCA needs further investigations.",
keywords = "Epidemiology, Giant cell arteritis, Meta-analysis, Systematic review, Temporal arteritis",
author = "Patompong Ungprasert and Sikarin Upala and Anawin Sanguankeo and Warrington, {Kenneth J}",
year = "2015",
month = "9",
day = "17",
doi = "10.3109/14397595.2015.1081722",
language = "English (US)",
journal = "Modern Rheumatology",
issn = "1439-7595",
publisher = "Springer Japan",

}

TY - JOUR

T1 - Patients with giant cell arteritis have a lower prevalence of diabetes mellitus

T2 - A systematic review and meta-analysis

AU - Ungprasert, Patompong

AU - Upala, Sikarin

AU - Sanguankeo, Anawin

AU - Warrington, Kenneth J

PY - 2015/9/17

Y1 - 2015/9/17

N2 - Objective: The aim of this study is to compare the prevalence of diabetes mellitus (DM) in patients who are recently diagnosed with giant cell arteritis (GCA) with age- and sex-matched controls. Methods: We conducted a systematic review and meta-analysis of observational studies that (1) consisted of GCA cohort and non-GCA cohort that was randomly selected from the same population and (2) provided prevalences of DM at the time of diagnosis for patients with GCA and at the index date for controls. Pooled odds ratios and 95% confidence intervals (CIs) were calculated using a random-effect, Mantel–Haenszel analysis. Results: Five studies with 903 patients with GCA and 1064 controls were identified and included in our data analysis. We demonstrated a statistically significant lower prevalence of DM among patients with GCA with the pooled OR of 0.74 (95% CI, 0.57–0.97). Conclusion: At diagnosis, patients with GCA had a lower prevalence of DM. Whether DM could be a protective factor against the development of GCA needs further investigations.

AB - Objective: The aim of this study is to compare the prevalence of diabetes mellitus (DM) in patients who are recently diagnosed with giant cell arteritis (GCA) with age- and sex-matched controls. Methods: We conducted a systematic review and meta-analysis of observational studies that (1) consisted of GCA cohort and non-GCA cohort that was randomly selected from the same population and (2) provided prevalences of DM at the time of diagnosis for patients with GCA and at the index date for controls. Pooled odds ratios and 95% confidence intervals (CIs) were calculated using a random-effect, Mantel–Haenszel analysis. Results: Five studies with 903 patients with GCA and 1064 controls were identified and included in our data analysis. We demonstrated a statistically significant lower prevalence of DM among patients with GCA with the pooled OR of 0.74 (95% CI, 0.57–0.97). Conclusion: At diagnosis, patients with GCA had a lower prevalence of DM. Whether DM could be a protective factor against the development of GCA needs further investigations.

KW - Epidemiology

KW - Giant cell arteritis

KW - Meta-analysis

KW - Systematic review

KW - Temporal arteritis

UR - http://www.scopus.com/inward/record.url?scp=84941750035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941750035&partnerID=8YFLogxK

U2 - 10.3109/14397595.2015.1081722

DO - 10.3109/14397595.2015.1081722

M3 - Article

C2 - 26381748

AN - SCOPUS:84941750035

JO - Modern Rheumatology

JF - Modern Rheumatology

SN - 1439-7595

ER -