Patients With Celiac Disease and B-Cell Lymphoma Have a Better Prognosis Than Those With T-Cell Lymphoma

Thorvardur R. Halfdanarson, Alberto Rubio-Tapia, Kay M. Ristow, Thomas Matthew Habermann, Joseph A Murray, David J. Inwards

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background & Aims: Celiac disease (CD) is associated with an increased risk of lymphoma. However, relatively few studies have assessed the outcome of patients diagnosed with both CD and lymphoma. We evaluated the temporal association between lymphoma and CD, along with clinical presentation, response to therapy, and prognosis. Methods: Patients diagnosed with both CD and lymphoma were identified retrospectively in a tertiary referral center. Clinical characteristics and survival were analyzed. Results: Sixty-three patients (36 men) were identified who had been diagnosed with lymphoma and CD. Thirty-six (57%) were diagnosed with CD before they were diagnosed with lymphoma. The most common histologic entity was diffuse, large, B-cell lymphoma, which affected 18 (29%) patients. Complete information for staging was available in 59 patients; 24 (38%) had stage IV disease. Only chemotherapy or only radiation therapy was used for 43 (68%) and 11 (17%) patients, respectively. The 5- and 10-year cumulative survival rates for the entire cohort were 58% and 39%, respectively. Survival of patients with T-cell lymphoma was shorter than for all other lymphomas (119.4 vs 22.8 mo; P = 02). Conclusions: CD is associated with B- and T-cell lymphomas. Patients with B-cell lymphomas had a better prognosis than those with T-cell lymphoma. Therapy is unsatisfactory for enteropathy-type T-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)1042-1047
Number of pages6
JournalClinical Gastroenterology and Hepatology
Volume8
Issue number12
DOIs
StatePublished - Dec 2010

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T-Cell Lymphoma
Celiac Disease
B-Cell Lymphoma
Lymphoma
Survival
Lymphoma, Large B-Cell, Diffuse
Tertiary Care Centers
Radiotherapy
Survival Rate
Drug Therapy
Therapeutics

Keywords

  • Cancer
  • Enteropathy
  • GI Disease
  • Gluten

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Patients With Celiac Disease and B-Cell Lymphoma Have a Better Prognosis Than Those With T-Cell Lymphoma. / Halfdanarson, Thorvardur R.; Rubio-Tapia, Alberto; Ristow, Kay M.; Habermann, Thomas Matthew; Murray, Joseph A; Inwards, David J.

In: Clinical Gastroenterology and Hepatology, Vol. 8, No. 12, 12.2010, p. 1042-1047.

Research output: Contribution to journalArticle

Halfdanarson, Thorvardur R. ; Rubio-Tapia, Alberto ; Ristow, Kay M. ; Habermann, Thomas Matthew ; Murray, Joseph A ; Inwards, David J. / Patients With Celiac Disease and B-Cell Lymphoma Have a Better Prognosis Than Those With T-Cell Lymphoma. In: Clinical Gastroenterology and Hepatology. 2010 ; Vol. 8, No. 12. pp. 1042-1047.
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