Abstract
We identified and analyzed 45 patients with asymptomatic primary sclerosing cholangitis to better understand the natural history of this disease. Disease progression was monitored at regular intervals for the development of symptoms and physical signs as well as changes in liver biochemistry, cholangiography, and liver histology. During a median follow-up of 75.2 mo, 34 patients (76%) had evidence of disease progression. Fourteen patients (31%) developed liver failure which resulted in death or referral for liver transplantation. For patients with primary sclerosing cholangitis, survival curves computed using the Kaplan-Meier method were significantly worse than expected when compared to age-, sex-, and race-specific survival rates for the United States north central population (p < 0.001). These findings indicate that primary sclerosing cholangitis is generally a progressive disease with considerable morbidity and mortality even when detected before the onset of symptoms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1594-1602 |
| Number of pages | 9 |
| Journal | Gastroenterology |
| Volume | 98 |
| Issue number | 6 |
| State | Published - 1990 |
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ASJC Scopus subject areas
- Gastroenterology
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Patients with asymptomatic primary sclerosing cholangitis frequently have progressive disease. / Porayko, Michael K.; Wiesner, Russell H.; La Russo, Nicholas F; Ludwig, Jurgen; MacCarty, Robert L.; Steiner, Betty L.; Twomey, Colleen K.; Zinsmeister, Alan R.
In: Gastroenterology, Vol. 98, No. 6, 1990, p. 1594-1602.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Patients with asymptomatic primary sclerosing cholangitis frequently have progressive disease
AU - Porayko, Michael K.
AU - Wiesner, Russell H.
AU - La Russo, Nicholas F
AU - Ludwig, Jurgen
AU - MacCarty, Robert L.
AU - Steiner, Betty L.
AU - Twomey, Colleen K.
AU - Zinsmeister, Alan R.
PY - 1990
Y1 - 1990
N2 - We identified and analyzed 45 patients with asymptomatic primary sclerosing cholangitis to better understand the natural history of this disease. Disease progression was monitored at regular intervals for the development of symptoms and physical signs as well as changes in liver biochemistry, cholangiography, and liver histology. During a median follow-up of 75.2 mo, 34 patients (76%) had evidence of disease progression. Fourteen patients (31%) developed liver failure which resulted in death or referral for liver transplantation. For patients with primary sclerosing cholangitis, survival curves computed using the Kaplan-Meier method were significantly worse than expected when compared to age-, sex-, and race-specific survival rates for the United States north central population (p < 0.001). These findings indicate that primary sclerosing cholangitis is generally a progressive disease with considerable morbidity and mortality even when detected before the onset of symptoms.
AB - We identified and analyzed 45 patients with asymptomatic primary sclerosing cholangitis to better understand the natural history of this disease. Disease progression was monitored at regular intervals for the development of symptoms and physical signs as well as changes in liver biochemistry, cholangiography, and liver histology. During a median follow-up of 75.2 mo, 34 patients (76%) had evidence of disease progression. Fourteen patients (31%) developed liver failure which resulted in death or referral for liver transplantation. For patients with primary sclerosing cholangitis, survival curves computed using the Kaplan-Meier method were significantly worse than expected when compared to age-, sex-, and race-specific survival rates for the United States north central population (p < 0.001). These findings indicate that primary sclerosing cholangitis is generally a progressive disease with considerable morbidity and mortality even when detected before the onset of symptoms.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025259858&partnerID=8YFLogxK
M3 - Article
C2 - 2338198
AN - SCOPUS:0025259858
VL - 98
SP - 1594
EP - 1602
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 6
ER -