Patient versus informant reporting of ICD symptoms in Parkinson's disease using the QUIP: Validity and variability

Kimberly Papay, Eugenia Mamikonyan, Andrew D. Siderowf, John E. Duda, Kelly E. Lyons, Rajesh Pahwa, Erika M Driver-Dunckley, Charles Howard Adler, Daniel Weintraub

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Questions exist regarding the validity of patient-reporting of psychiatric symptoms in Parkinson's disease (PD). We assessed observer variability and validity in reporting of impulse control disorder (ICD) symptoms in PD by using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP). PD patients and their informants (71 pairs) completed the QUIP to assess four ICDs (compulsive gambling, buying, sexual behavior, and eating) in patients. Trained raters then administered a diagnostic interview. Sensitivity of the QUIP for a diagnosed ICD was 100% for both patient- and informant-completed instruments, and specificity was 75% for both raters. Approximately 40% of patients without an ICD diagnosis had a positive QUIP, suggesting that many PD patients experience subsyndromal ICD symptoms that require ongoing monitoring. Agreement between patient- and informant-reporting of any ICD behaviors on the QUIP was moderate (kappa = 0.408), and for individual ICDs was highest for gambling (kappa = 0.550). Overall, a negative QUIP from either the patient or informant rules out the possibility of an ICD, while a positive QUIP requires a follow-up diagnostic interview and ongoing monitoring to determine if symptoms currently are, or in the future become, clinically significant.

Original languageEnglish (US)
Pages (from-to)153-155
Number of pages3
JournalParkinsonism and Related Disorders
Volume17
Issue number3
DOIs
StatePublished - Mar 2011

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Disruptive, Impulse Control, and Conduct Disorders
Parkinson Disease
Gambling
Interviews
Sexual Behavior
Psychiatry
Eating

Keywords

  • Impulse control disorders
  • Parkinson's disease
  • QUIP

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Patient versus informant reporting of ICD symptoms in Parkinson's disease using the QUIP : Validity and variability. / Papay, Kimberly; Mamikonyan, Eugenia; Siderowf, Andrew D.; Duda, John E.; Lyons, Kelly E.; Pahwa, Rajesh; Driver-Dunckley, Erika M; Adler, Charles Howard; Weintraub, Daniel.

In: Parkinsonism and Related Disorders, Vol. 17, No. 3, 03.2011, p. 153-155.

Research output: Contribution to journalArticle

Papay, Kimberly ; Mamikonyan, Eugenia ; Siderowf, Andrew D. ; Duda, John E. ; Lyons, Kelly E. ; Pahwa, Rajesh ; Driver-Dunckley, Erika M ; Adler, Charles Howard ; Weintraub, Daniel. / Patient versus informant reporting of ICD symptoms in Parkinson's disease using the QUIP : Validity and variability. In: Parkinsonism and Related Disorders. 2011 ; Vol. 17, No. 3. pp. 153-155.
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