Patient-reported physical functioning predicts the success of hematopoietic cell transplantation (BMT CTN 0902)

William A. Wood, Jennifer Le-Rademacher, Karen L. Syrjala, Heather Jim, Paul B. Jacobsen, Jennifer M. Knight, Muneer H. Abidi, John R. Wingard, Navneet S. Majhail, Nancy L. Geller, J. Douglas Rizzo, Mingwei Fei, Juan Wu, Mary M. Horowitz, Stephanie J. Lee

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

BACKGROUND In hematopoietic cell transplantation (HCT), current risk adjustment strategies are based on clinical and disease-related variables. Although patient-reported outcomes (PROs) predict mortality in multiple cancers, they have been less well studied within HCT. Improvements in risk adjustment strategies in HCT would inform patient selection, patient counseling, and quality reporting. The objective of the current study was to determine whether pre-HCT PROs, in particular physical health, predict survival among patients undergoing autologous or allogeneic transplantation. METHODS In this secondary analysis, the authors studied pre-HCT PROs that were reported by 336 allogeneic and 310 autologous HCT recipients enrolled in the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902 protocol, a study with broad representation of patients who underwent transplantation in the United States. RESULTS Among allogeneic HCT recipients, the pre-HCT Medical Outcomes Study Short Form-36 Health Survey (SF-36) physical component summary (PCS) scale independently predicted overall mortality (hazards ratio, 1.40 per 10-point decrease; P<.001) and performed at least as well as currently used, non-PRO risk indices. Survival probability estimates at 1 year for the first, second, third, and fourth quartiles of the baseline PCS were 50%, 65%, 75%, and 83%, respectively. Early post-HCT decreases in PCS were associated with higher overall and treatment-related mortality. When adjusted for patient variables included in the US Stem Cell Therapeutic Outcomes Database model for transplant center-specific reporting, the SF-36 PCS retained independent prognostic value. CONCLUSIONS PROs have the potential to improve prognostication in HCT. The authors recommend the routine collection of PROs before HCT, and consideration of the incorporation of PROs into risk adjustment for quality reporting. Cancer 2016;122:91-98. Pretransplant physical health, as measured by the physical component summary scale of the Medical Outcomes Study Short Form-36 Health Survey (SF-36), appears to be strongly prognostic for overall and transplant-related mortality in allogeneic hematopoietic cell transplantation recipients enrolled on the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902 protocol, a study that was broadly representative of the general transplant population in clinical practice. Patient-reported outcomes may play a role in patient selection, patient counseling, and quality reporting in hematopoietic cell transplantation.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalCancer
Volume122
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Cell Transplantation
Bone Marrow
Clinical Trials
Transplants
Risk Adjustment
Mortality
Health Surveys
Patient Selection
Counseling
Outcome Assessment (Health Care)
Survival
Autologous Transplantation
Homologous Transplantation
Health
Patient Reported Outcome Measures
Neoplasms
Stem Cells
Transplantation

Keywords

  • hematopoietic stem cell transplantation
  • outcome assessment
  • physical fitness
  • quality of life
  • risk adjustment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Patient-reported physical functioning predicts the success of hematopoietic cell transplantation (BMT CTN 0902). / Wood, William A.; Le-Rademacher, Jennifer; Syrjala, Karen L.; Jim, Heather; Jacobsen, Paul B.; Knight, Jennifer M.; Abidi, Muneer H.; Wingard, John R.; Majhail, Navneet S.; Geller, Nancy L.; Rizzo, J. Douglas; Fei, Mingwei; Wu, Juan; Horowitz, Mary M.; Lee, Stephanie J.

In: Cancer, Vol. 122, No. 1, 01.01.2016, p. 91-98.

Research output: Contribution to journalArticle

Wood, WA, Le-Rademacher, J, Syrjala, KL, Jim, H, Jacobsen, PB, Knight, JM, Abidi, MH, Wingard, JR, Majhail, NS, Geller, NL, Rizzo, JD, Fei, M, Wu, J, Horowitz, MM & Lee, SJ 2016, 'Patient-reported physical functioning predicts the success of hematopoietic cell transplantation (BMT CTN 0902)', Cancer, vol. 122, no. 1, pp. 91-98. https://doi.org/10.1002/cncr.29717
Wood, William A. ; Le-Rademacher, Jennifer ; Syrjala, Karen L. ; Jim, Heather ; Jacobsen, Paul B. ; Knight, Jennifer M. ; Abidi, Muneer H. ; Wingard, John R. ; Majhail, Navneet S. ; Geller, Nancy L. ; Rizzo, J. Douglas ; Fei, Mingwei ; Wu, Juan ; Horowitz, Mary M. ; Lee, Stephanie J. / Patient-reported physical functioning predicts the success of hematopoietic cell transplantation (BMT CTN 0902). In: Cancer. 2016 ; Vol. 122, No. 1. pp. 91-98.
@article{60a58dcda6ef4ee4a1e37753be49cc0f,
title = "Patient-reported physical functioning predicts the success of hematopoietic cell transplantation (BMT CTN 0902)",
abstract = "BACKGROUND In hematopoietic cell transplantation (HCT), current risk adjustment strategies are based on clinical and disease-related variables. Although patient-reported outcomes (PROs) predict mortality in multiple cancers, they have been less well studied within HCT. Improvements in risk adjustment strategies in HCT would inform patient selection, patient counseling, and quality reporting. The objective of the current study was to determine whether pre-HCT PROs, in particular physical health, predict survival among patients undergoing autologous or allogeneic transplantation. METHODS In this secondary analysis, the authors studied pre-HCT PROs that were reported by 336 allogeneic and 310 autologous HCT recipients enrolled in the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902 protocol, a study with broad representation of patients who underwent transplantation in the United States. RESULTS Among allogeneic HCT recipients, the pre-HCT Medical Outcomes Study Short Form-36 Health Survey (SF-36) physical component summary (PCS) scale independently predicted overall mortality (hazards ratio, 1.40 per 10-point decrease; P<.001) and performed at least as well as currently used, non-PRO risk indices. Survival probability estimates at 1 year for the first, second, third, and fourth quartiles of the baseline PCS were 50{\%}, 65{\%}, 75{\%}, and 83{\%}, respectively. Early post-HCT decreases in PCS were associated with higher overall and treatment-related mortality. When adjusted for patient variables included in the US Stem Cell Therapeutic Outcomes Database model for transplant center-specific reporting, the SF-36 PCS retained independent prognostic value. CONCLUSIONS PROs have the potential to improve prognostication in HCT. The authors recommend the routine collection of PROs before HCT, and consideration of the incorporation of PROs into risk adjustment for quality reporting. Cancer 2016;122:91-98. Pretransplant physical health, as measured by the physical component summary scale of the Medical Outcomes Study Short Form-36 Health Survey (SF-36), appears to be strongly prognostic for overall and transplant-related mortality in allogeneic hematopoietic cell transplantation recipients enrolled on the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902 protocol, a study that was broadly representative of the general transplant population in clinical practice. Patient-reported outcomes may play a role in patient selection, patient counseling, and quality reporting in hematopoietic cell transplantation.",
keywords = "hematopoietic stem cell transplantation, outcome assessment, physical fitness, quality of life, risk adjustment",
author = "Wood, {William A.} and Jennifer Le-Rademacher and Syrjala, {Karen L.} and Heather Jim and Jacobsen, {Paul B.} and Knight, {Jennifer M.} and Abidi, {Muneer H.} and Wingard, {John R.} and Majhail, {Navneet S.} and Geller, {Nancy L.} and Rizzo, {J. Douglas} and Mingwei Fei and Juan Wu and Horowitz, {Mary M.} and Lee, {Stephanie J.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1002/cncr.29717",
language = "English (US)",
volume = "122",
pages = "91--98",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Patient-reported physical functioning predicts the success of hematopoietic cell transplantation (BMT CTN 0902)

AU - Wood, William A.

AU - Le-Rademacher, Jennifer

AU - Syrjala, Karen L.

AU - Jim, Heather

AU - Jacobsen, Paul B.

AU - Knight, Jennifer M.

AU - Abidi, Muneer H.

AU - Wingard, John R.

AU - Majhail, Navneet S.

AU - Geller, Nancy L.

AU - Rizzo, J. Douglas

AU - Fei, Mingwei

AU - Wu, Juan

AU - Horowitz, Mary M.

AU - Lee, Stephanie J.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - BACKGROUND In hematopoietic cell transplantation (HCT), current risk adjustment strategies are based on clinical and disease-related variables. Although patient-reported outcomes (PROs) predict mortality in multiple cancers, they have been less well studied within HCT. Improvements in risk adjustment strategies in HCT would inform patient selection, patient counseling, and quality reporting. The objective of the current study was to determine whether pre-HCT PROs, in particular physical health, predict survival among patients undergoing autologous or allogeneic transplantation. METHODS In this secondary analysis, the authors studied pre-HCT PROs that were reported by 336 allogeneic and 310 autologous HCT recipients enrolled in the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902 protocol, a study with broad representation of patients who underwent transplantation in the United States. RESULTS Among allogeneic HCT recipients, the pre-HCT Medical Outcomes Study Short Form-36 Health Survey (SF-36) physical component summary (PCS) scale independently predicted overall mortality (hazards ratio, 1.40 per 10-point decrease; P<.001) and performed at least as well as currently used, non-PRO risk indices. Survival probability estimates at 1 year for the first, second, third, and fourth quartiles of the baseline PCS were 50%, 65%, 75%, and 83%, respectively. Early post-HCT decreases in PCS were associated with higher overall and treatment-related mortality. When adjusted for patient variables included in the US Stem Cell Therapeutic Outcomes Database model for transplant center-specific reporting, the SF-36 PCS retained independent prognostic value. CONCLUSIONS PROs have the potential to improve prognostication in HCT. The authors recommend the routine collection of PROs before HCT, and consideration of the incorporation of PROs into risk adjustment for quality reporting. Cancer 2016;122:91-98. Pretransplant physical health, as measured by the physical component summary scale of the Medical Outcomes Study Short Form-36 Health Survey (SF-36), appears to be strongly prognostic for overall and transplant-related mortality in allogeneic hematopoietic cell transplantation recipients enrolled on the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902 protocol, a study that was broadly representative of the general transplant population in clinical practice. Patient-reported outcomes may play a role in patient selection, patient counseling, and quality reporting in hematopoietic cell transplantation.

AB - BACKGROUND In hematopoietic cell transplantation (HCT), current risk adjustment strategies are based on clinical and disease-related variables. Although patient-reported outcomes (PROs) predict mortality in multiple cancers, they have been less well studied within HCT. Improvements in risk adjustment strategies in HCT would inform patient selection, patient counseling, and quality reporting. The objective of the current study was to determine whether pre-HCT PROs, in particular physical health, predict survival among patients undergoing autologous or allogeneic transplantation. METHODS In this secondary analysis, the authors studied pre-HCT PROs that were reported by 336 allogeneic and 310 autologous HCT recipients enrolled in the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902 protocol, a study with broad representation of patients who underwent transplantation in the United States. RESULTS Among allogeneic HCT recipients, the pre-HCT Medical Outcomes Study Short Form-36 Health Survey (SF-36) physical component summary (PCS) scale independently predicted overall mortality (hazards ratio, 1.40 per 10-point decrease; P<.001) and performed at least as well as currently used, non-PRO risk indices. Survival probability estimates at 1 year for the first, second, third, and fourth quartiles of the baseline PCS were 50%, 65%, 75%, and 83%, respectively. Early post-HCT decreases in PCS were associated with higher overall and treatment-related mortality. When adjusted for patient variables included in the US Stem Cell Therapeutic Outcomes Database model for transplant center-specific reporting, the SF-36 PCS retained independent prognostic value. CONCLUSIONS PROs have the potential to improve prognostication in HCT. The authors recommend the routine collection of PROs before HCT, and consideration of the incorporation of PROs into risk adjustment for quality reporting. Cancer 2016;122:91-98. Pretransplant physical health, as measured by the physical component summary scale of the Medical Outcomes Study Short Form-36 Health Survey (SF-36), appears to be strongly prognostic for overall and transplant-related mortality in allogeneic hematopoietic cell transplantation recipients enrolled on the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902 protocol, a study that was broadly representative of the general transplant population in clinical practice. Patient-reported outcomes may play a role in patient selection, patient counseling, and quality reporting in hematopoietic cell transplantation.

KW - hematopoietic stem cell transplantation

KW - outcome assessment

KW - physical fitness

KW - quality of life

KW - risk adjustment

UR - http://www.scopus.com/inward/record.url?scp=84947968582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947968582&partnerID=8YFLogxK

U2 - 10.1002/cncr.29717

DO - 10.1002/cncr.29717

M3 - Article

C2 - 26439325

AN - SCOPUS:84947968582

VL - 122

SP - 91

EP - 98

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 1

ER -