Patient-reported functional outcomes in a cohort of hand and foot sarcoma survivors treated with limb sparing surgery and radiation therapy

Safia K. Ahmed, Suneetha Kaggal, William S. Harmsen, Jessica W. Sawyer, Matthew T. Houdek, Peter S. Rose, Ivy A. Petersen

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives: Describe patient-reported functional outcomes for hand and foot sarcoma survivors treated with limb-sparing surgery and radiation therapy (LSS + RT). Methods: Fifty-four patients with hand/wrist and foot/ankle sarcomas treated with LSS + RT from 1991 to 2015 were identified. Survivors ≥18 years old without subsequent amputation completed self-assessed functional surveys: Toronto upper extremity salvage score (TESS-UE) and Michigan hand outcomes (MHQ) surveys for hand; TESS lower extremity (TESS-LE) and Foot and Ankle Outcomes (FAOS) surveys for foot. Scoring scales: 0–100, MHQ and TESS; -26 to 56 and 25-59, FAOS core and shoe comfort, respectively. Higher scores denote superior function. Results: Five-year local tumor control was 88%. Fourteen of 24 hand (58%) and 14/18 foot (78%) survivors completed surveys. Mean TESS-UE and MHQ scores were 89.4 and 72.8, respectively. Mean TESS-LE, core FAOS, and shoe comfort scores were 92.4, 46.19, and 53.1, respectively. No factors correlated with outcomes. TESS-UE and MHQ scores strongly correlated (r =.87). TESS-LE and FAOS scores were associated with a poor correlation (r =.02 and r =.69). Conclusions: The largest patient-reported functional outcomes analysis for hand and foot sarcoma survivors treated with LSS + RT demonstrates excellent local tumor control and acceptable functional outcomes. Further exploration of optimal functional assessment tools is needed given the potential scope differences.

Original languageEnglish (US)
Pages (from-to)110-116
Number of pages7
JournalJournal of Surgical Oncology
Volume123
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • functional outcomes
  • hand and foot sarcoma
  • limb salvage surgery
  • radiation therapy

ASJC Scopus subject areas

  • Surgery
  • Oncology

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