Paths of least flow-resistance: Characterization for the optimization of synthetic tissue scaffold design

Timothy L. Kline, Erik L. Ritman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

A method for the analysis of preferred fluid movement into and out of porous specimen's pore networks has been developed that characterizes the flow pathways inside a pore network, an important property for the design of future synthetic tissue scaffolds. Current tissue scaffolds rely on diffusion as the solute transport mechanism for the sustenance and growth of cells into the scaffold's pore network. Utilizing convective transport induced by periodic scaffold deformation or subjecting the scaffold to a fluid pressure gradient are proposed methods for delivery/removal of nutrients/metabolic waste products. These future designs require an understanding of the flow properties of the designed scaffold. The developed method for characterizing the paths of least flowresistance is applied to a computer model porous scaffold, a synthetic porous tissue scaffold, and a sea sponge.

Original languageEnglish (US)
Title of host publicationProceedings - 2009 IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2009
Pages606-609
Number of pages4
DOIs
StatePublished - Nov 17 2009
Event2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009 - Boston, MA, United States
Duration: Jun 28 2009Jul 1 2009

Publication series

NameProceedings - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009

Other

Other2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009
CountryUnited States
CityBoston, MA
Period6/28/097/1/09

Keywords

  • Fast marching
  • Hagen-poiseuille
  • Porous materials
  • Sea sponge
  • Skeletonization

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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