Pathophysiology of Progression: Organ and Cellular Considerations

Anupam Agarwal; Karl A Nath

doi:10.1016/B978-0-12-411602-3.00012-3

Pathophysiology of Progression: Organ and Cellular Considerations

Anupam Agarwal, Karl A Nath

Nephrology and Hypertension

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

A steady functional decline in surviving nephrons and increasing nephron dropout underlie the progression of chronic kidney disease (CKD). A concept common to all mechanisms implicated in the progression of CKD is that processes centered in a particular renal compartment [en dash] glomerular, tubular, interstitial, vascular [en dash] recruit injurious processes in others, and it is this increasing recruitment and interplay of diverse pathobiologic processes, involving multiple renal compartments, that underlie progressive CKD. This chapter reviews these processes and their interaction in the progression of CKD, along with the role of specific mediators and inhibitors of CKD.

Original language	English (US)
Title of host publication	Chronic Renal Disease
Publisher	Elsevier Inc.
Pages	136-150
Number of pages	15
ISBN (Print)	9780124116160, 9780124116023
DOIs	https://doi.org/10.1016/B978-0-12-411602-3.00012-3
State	Published - Sep 24 2014

Keywords

Chronic kidney disease
Growth factors
Oxidative stress
Proteinuria
Renin-angiotensin

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-411602-3.00012-3

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abstract = "A steady functional decline in surviving nephrons and increasing nephron dropout underlie the progression of chronic kidney disease (CKD). A concept common to all mechanisms implicated in the progression of CKD is that processes centered in a particular renal compartment [en dash] glomerular, tubular, interstitial, vascular [en dash] recruit injurious processes in others, and it is this increasing recruitment and interplay of diverse pathobiologic processes, involving multiple renal compartments, that underlie progressive CKD. This chapter reviews these processes and their interaction in the progression of CKD, along with the role of specific mediators and inhibitors of CKD.",

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N2 - A steady functional decline in surviving nephrons and increasing nephron dropout underlie the progression of chronic kidney disease (CKD). A concept common to all mechanisms implicated in the progression of CKD is that processes centered in a particular renal compartment [en dash] glomerular, tubular, interstitial, vascular [en dash] recruit injurious processes in others, and it is this increasing recruitment and interplay of diverse pathobiologic processes, involving multiple renal compartments, that underlie progressive CKD. This chapter reviews these processes and their interaction in the progression of CKD, along with the role of specific mediators and inhibitors of CKD.

AB - A steady functional decline in surviving nephrons and increasing nephron dropout underlie the progression of chronic kidney disease (CKD). A concept common to all mechanisms implicated in the progression of CKD is that processes centered in a particular renal compartment [en dash] glomerular, tubular, interstitial, vascular [en dash] recruit injurious processes in others, and it is this increasing recruitment and interplay of diverse pathobiologic processes, involving multiple renal compartments, that underlie progressive CKD. This chapter reviews these processes and their interaction in the progression of CKD, along with the role of specific mediators and inhibitors of CKD.

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KW - Growth factors

KW - Oxidative stress

KW - Proteinuria

KW - Renin-angiotensin

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ER -

Pathophysiology of Progression: Organ and Cellular Considerations

Abstract

Keywords

ASJC Scopus subject areas

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