Pathophysiology of postoperative ileus

J. Smith, K. A. Kelly, Richard M Weinshilboum

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

In eight dogs, celiotomy, rubbing the small bowel, and exposing it to air suppressed the migrating bursts of action potentials and contractions that occur in the gastrointestinal tract during fasting and greatly slowed (one to three days) the gastrointestinal transit of 7-mm plastic spheres. The operation also caused a transient one-day increase in the concentration of epinephrine and a more prolonged five-day increase in the concentration and norepinephrine in arterial and venous plasma. Phentolamine mesylate and propranolol hydrochloride prevented the inhibition of the bursts of gastric action potentials brought about by operation, but these drugs did not alter the inhibition of the small intestinal action potentials or the speed of gastrointestinal transit of spheres.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalArchives of Surgery
Volume112
Issue number2
StatePublished - 1977

Fingerprint

Ileus
Gastrointestinal Transit
Action Potentials
Phentolamine
Propranolol
Epinephrine
Plastics
Gastrointestinal Tract
Fasting
Stomach
Norepinephrine
Air
Dogs
Pharmaceutical Preparations
Inhibition (Psychology)

ASJC Scopus subject areas

  • Surgery

Cite this

Pathophysiology of postoperative ileus. / Smith, J.; Kelly, K. A.; Weinshilboum, Richard M.

In: Archives of Surgery, Vol. 112, No. 2, 1977, p. 203-209.

Research output: Contribution to journalArticle

Smith, J, Kelly, KA & Weinshilboum, RM 1977, 'Pathophysiology of postoperative ileus', Archives of Surgery, vol. 112, no. 2, pp. 203-209.
Smith, J. ; Kelly, K. A. ; Weinshilboum, Richard M. / Pathophysiology of postoperative ileus. In: Archives of Surgery. 1977 ; Vol. 112, No. 2. pp. 203-209.
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