Abstract
Although most meningiomas are benign and are treated with surgery alone, a few are malignant and can be difficult to treat. These more aggressive tumors were first characterized by their histology. With advances in molecular biology, we have learned a great deal about the development of these tumors. Cytogenetic studies have shown that benign meningiomas have mutations in chromosome 22. Further studies show that the NF2 gene, located on chromosome 22, is involved in meningioma formation. More aggressive tumors have been shown to have several mutations in other chromosomes, including chromosome 1p, 14q, and 18q. Here, we review these findings and the candidate genes involved in meningioma tumorigenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 187-192 |
| Number of pages | 6 |
| Journal | Seminars in Neurosurgery |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2003 |
| Externally published | Yes |
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Keywords
- ALPL
- DAL-1
- Malignant meningioma
- Merlin
- NF2
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Pathophysiology of malignant meningiomas. / Ware, Marcus L.; Quinones-Hinojosa, Alfredo; McDermott, Michael W.
In: Seminars in Neurosurgery, Vol. 14, No. 3, 09.2003, p. 187-192.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Pathophysiology of malignant meningiomas
AU - Ware, Marcus L.
AU - Quinones-Hinojosa, Alfredo
AU - McDermott, Michael W.
PY - 2003/9
Y1 - 2003/9
N2 - Although most meningiomas are benign and are treated with surgery alone, a few are malignant and can be difficult to treat. These more aggressive tumors were first characterized by their histology. With advances in molecular biology, we have learned a great deal about the development of these tumors. Cytogenetic studies have shown that benign meningiomas have mutations in chromosome 22. Further studies show that the NF2 gene, located on chromosome 22, is involved in meningioma formation. More aggressive tumors have been shown to have several mutations in other chromosomes, including chromosome 1p, 14q, and 18q. Here, we review these findings and the candidate genes involved in meningioma tumorigenesis.
AB - Although most meningiomas are benign and are treated with surgery alone, a few are malignant and can be difficult to treat. These more aggressive tumors were first characterized by their histology. With advances in molecular biology, we have learned a great deal about the development of these tumors. Cytogenetic studies have shown that benign meningiomas have mutations in chromosome 22. Further studies show that the NF2 gene, located on chromosome 22, is involved in meningioma formation. More aggressive tumors have been shown to have several mutations in other chromosomes, including chromosome 1p, 14q, and 18q. Here, we review these findings and the candidate genes involved in meningioma tumorigenesis.
KW - ALPL
KW - DAL-1
KW - Malignant meningioma
KW - Merlin
KW - NF2
UR - http://www.scopus.com/inward/record.url?scp=2442657983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2442657983&partnerID=8YFLogxK
U2 - 10.1055/s-2004-817735
DO - 10.1055/s-2004-817735
M3 - Review article
VL - 14
SP - 187
EP - 192
JO - Seminars in Neurosurgery
JF - Seminars in Neurosurgery
SN - 1526-8012
IS - 3
ER -