TY - JOUR
T1 - Pathophysiology of Male Hypogonadism Associated with Endogenous Hyperestrogenism
T2 - Evidence for Dual Defects in the Gonadal Axis
AU - Veldhuis, Johannes D.
AU - Sowers, James R.
AU - Rogol, Alan D.
AU - Klein, Frederick A.
AU - Miller, Norman
AU - Dufau, Maria L.
PY - 1985/5/23
Y1 - 1985/5/23
N2 - FEMINIZING tumors of the adrenal cortex are associated with symptoms that presumably reflect the combined effects of estrogen excess and androgen deficiency — gynecomastia, diminished libido, attenuated potency, and testicular and prostatic atrophy.1 2 3 4 5 Although such tumors are extremely rare, they provide a unique opportunity to appraise the nature of endogenous estrogen action on the gonadal axis in men. In principle, the pathophysiologic effects of estrogen hypersecretion could be expressed at the level of either the Leydig cell or the hypothalamic–pituitary axis (or both), with consequent suppression of androgen production. In the present studies, we investigated the endocrine consequences of reversible.
AB - FEMINIZING tumors of the adrenal cortex are associated with symptoms that presumably reflect the combined effects of estrogen excess and androgen deficiency — gynecomastia, diminished libido, attenuated potency, and testicular and prostatic atrophy.1 2 3 4 5 Although such tumors are extremely rare, they provide a unique opportunity to appraise the nature of endogenous estrogen action on the gonadal axis in men. In principle, the pathophysiologic effects of estrogen hypersecretion could be expressed at the level of either the Leydig cell or the hypothalamic–pituitary axis (or both), with consequent suppression of androgen production. In the present studies, we investigated the endocrine consequences of reversible.
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U2 - 10.1056/NEJM198505233122107
DO - 10.1056/NEJM198505233122107
M3 - Article
C2 - 3990735
AN - SCOPUS:0021912308
SN - 0028-4793
VL - 312
SP - 1371
EP - 1375
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 21
ER -