Pathophysiology of male hypogonadism associated with endogenous hyperestrogenism. Evidence for dual defects in the gonadal axis

Johannes D Veldhuis, J. R. Sowers, A. D. Rogol, F. A. Klein, N. Miller, M. L. Dufau

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Severe but reversible male hypogonadism associated with endogenous hyperestrogenism can be attributable to profound suppression of circulating concentrations of biologically active LH, with an associated steroidal pattern that mimics that of estrogen-induced steroidogenic lesions in the Leydig cells of laboratory animals. Thus, we suggest that a sustained estrogen excess could induce hypogonadism in men by imposing dual lesions on the gonadal axis-by suppressing the secretion of biologically active LH and by adversely affecting Leydig-cell function.

Original languageEnglish (US)
Pages (from-to)1371-1375
Number of pages5
JournalNew England Journal of Medicine
Volume312
Issue number21
StatePublished - 1985
Externally publishedYes

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Eunuchism
Leydig Cells
Estrogens
Hypogonadism
Laboratory Animals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Veldhuis, J. D., Sowers, J. R., Rogol, A. D., Klein, F. A., Miller, N., & Dufau, M. L. (1985). Pathophysiology of male hypogonadism associated with endogenous hyperestrogenism. Evidence for dual defects in the gonadal axis. New England Journal of Medicine, 312(21), 1371-1375.

Pathophysiology of male hypogonadism associated with endogenous hyperestrogenism. Evidence for dual defects in the gonadal axis. / Veldhuis, Johannes D; Sowers, J. R.; Rogol, A. D.; Klein, F. A.; Miller, N.; Dufau, M. L.

In: New England Journal of Medicine, Vol. 312, No. 21, 1985, p. 1371-1375.

Research output: Contribution to journalArticle

Veldhuis, JD, Sowers, JR, Rogol, AD, Klein, FA, Miller, N & Dufau, ML 1985, 'Pathophysiology of male hypogonadism associated with endogenous hyperestrogenism. Evidence for dual defects in the gonadal axis', New England Journal of Medicine, vol. 312, no. 21, pp. 1371-1375.
Veldhuis, Johannes D ; Sowers, J. R. ; Rogol, A. D. ; Klein, F. A. ; Miller, N. ; Dufau, M. L. / Pathophysiology of male hypogonadism associated with endogenous hyperestrogenism. Evidence for dual defects in the gonadal axis. In: New England Journal of Medicine. 1985 ; Vol. 312, No. 21. pp. 1371-1375.
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