Abstract
The main function of the Lower Esophageal Sphincter (LES) is to serve as a barrier to protect the esophageal mucosa and more proximal structures from potentially damaging substances. Incompetence in some form of the LES is the predominant determinant of GERD. This article reviews the three main LES defects that lead to GERD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 44-58 |
| Number of pages | 15 |
| Journal | Practical Gastroenterology |
| Volume | 28 |
| Issue number | 5 |
| State | Published - May 2004 |
ASJC Scopus subject areas
- Gastroenterology