TY - JOUR
T1 - Pathophysiology of Degenerative Mitral Regurgitation
T2 - New 3-Dimensional Imaging Insights
AU - Antoine, Clemence
AU - Mantovani, Francesca
AU - Benfari, Giovanni
AU - Mankad, Sunil V.
AU - Maalouf, Joseph F.
AU - Michelena, Hector I.
AU - Enriquez-Sarano, Maurice
N1 - Publisher Copyright:
© 2018 American Heart Association, Inc.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Despite its high prevalence, little is known about mechanisms of mitral regurgitation in degenerative mitral valve disease apart from the leaflet prolapse itself. Mitral valve is a complex structure, including mitral annulus, mitral leaflets, papillary muscles, chords, and left ventricular walls. All these structures are involved in physiological and pathological functioning of this valvuloventricular complex but up to now were difficult to analyze because of inherent limitations of 2-dimensional imaging. The advent of 3-dimensional echocardiography, computed tomography, and cardiac magnetic resonance imaging overcoming these limitations provides new insights into mechanistic analysis of degenerative mitral regurgitation. This review will detail the contribution of quantitative and qualitative dynamic analysis of mitral annulus and mitral leaflets by new imaging methods in the understanding of degenerative mitral regurgitation pathophysiology.
AB - Despite its high prevalence, little is known about mechanisms of mitral regurgitation in degenerative mitral valve disease apart from the leaflet prolapse itself. Mitral valve is a complex structure, including mitral annulus, mitral leaflets, papillary muscles, chords, and left ventricular walls. All these structures are involved in physiological and pathological functioning of this valvuloventricular complex but up to now were difficult to analyze because of inherent limitations of 2-dimensional imaging. The advent of 3-dimensional echocardiography, computed tomography, and cardiac magnetic resonance imaging overcoming these limitations provides new insights into mechanistic analysis of degenerative mitral regurgitation. This review will detail the contribution of quantitative and qualitative dynamic analysis of mitral annulus and mitral leaflets by new imaging methods in the understanding of degenerative mitral regurgitation pathophysiology.
KW - echocardiography
KW - heart ventricles
KW - magnetic resonance imaging
KW - mitral valve
KW - papillary muscles
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U2 - 10.1161/CIRCIMAGING.116.005971
DO - 10.1161/CIRCIMAGING.116.005971
M3 - Review article
C2 - 29321211
AN - SCOPUS:85052808405
SN - 1941-9651
VL - 11
SP - e005971
JO - Circulation. Cardiovascular imaging
JF - Circulation. Cardiovascular imaging
IS - 1
ER -