Pathophysiology of chronic constipation and IBS

Research output: Contribution to journalArticle

Abstract

The pathophysiology of chronic constipation and irritable bowel syndrome (IBS) involves consideration of disturbances in colonic sensorimotor activity, often resulting from disordered extrinsic and/or intrinsic innervations. The mechanisms by which normal colonic activity is altered to cause constipation or IBS are complex, as are the enteric neuropathologic changes that are present in some patients with slow-transit constipation and the serotoninergic disturbances in patients with IBS. Using normal colonic motor patterns and functions as a starting point, this article explores these processes in some detail. It also addresses the assessment of colonic sensorimotor function, the causes of slow-transit constipation, the role of high-amplitude propagated contractions and loss of interstitial cells of Cajal in constipation, the role of serotonin in the gut, and the serotoninergic disturbances in IBS.

Original languageEnglish (US)
JournalAdvanced Studies in Medicine
Volume6
Issue number2 A
StatePublished - Feb 2006

Fingerprint

Irritable Bowel Syndrome
Constipation
Interstitial Cells of Cajal
Serotonin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pathophysiology of chronic constipation and IBS. / Bharucha, Adil Eddie.

In: Advanced Studies in Medicine, Vol. 6, No. 2 A, 02.2006.

Research output: Contribution to journalArticle

@article{56f8e39d74394e83af4a88d227dd15c0,
title = "Pathophysiology of chronic constipation and IBS",
abstract = "The pathophysiology of chronic constipation and irritable bowel syndrome (IBS) involves consideration of disturbances in colonic sensorimotor activity, often resulting from disordered extrinsic and/or intrinsic innervations. The mechanisms by which normal colonic activity is altered to cause constipation or IBS are complex, as are the enteric neuropathologic changes that are present in some patients with slow-transit constipation and the serotoninergic disturbances in patients with IBS. Using normal colonic motor patterns and functions as a starting point, this article explores these processes in some detail. It also addresses the assessment of colonic sensorimotor function, the causes of slow-transit constipation, the role of high-amplitude propagated contractions and loss of interstitial cells of Cajal in constipation, the role of serotonin in the gut, and the serotoninergic disturbances in IBS.",
author = "Bharucha, {Adil Eddie}",
year = "2006",
month = "2",
language = "English (US)",
volume = "6",
journal = "Advanced Studies in Medicine",
issn = "1530-3004",
publisher = "Galen Publishing LLC",
number = "2 A",

}

TY - JOUR

T1 - Pathophysiology of chronic constipation and IBS

AU - Bharucha, Adil Eddie

PY - 2006/2

Y1 - 2006/2

N2 - The pathophysiology of chronic constipation and irritable bowel syndrome (IBS) involves consideration of disturbances in colonic sensorimotor activity, often resulting from disordered extrinsic and/or intrinsic innervations. The mechanisms by which normal colonic activity is altered to cause constipation or IBS are complex, as are the enteric neuropathologic changes that are present in some patients with slow-transit constipation and the serotoninergic disturbances in patients with IBS. Using normal colonic motor patterns and functions as a starting point, this article explores these processes in some detail. It also addresses the assessment of colonic sensorimotor function, the causes of slow-transit constipation, the role of high-amplitude propagated contractions and loss of interstitial cells of Cajal in constipation, the role of serotonin in the gut, and the serotoninergic disturbances in IBS.

AB - The pathophysiology of chronic constipation and irritable bowel syndrome (IBS) involves consideration of disturbances in colonic sensorimotor activity, often resulting from disordered extrinsic and/or intrinsic innervations. The mechanisms by which normal colonic activity is altered to cause constipation or IBS are complex, as are the enteric neuropathologic changes that are present in some patients with slow-transit constipation and the serotoninergic disturbances in patients with IBS. Using normal colonic motor patterns and functions as a starting point, this article explores these processes in some detail. It also addresses the assessment of colonic sensorimotor function, the causes of slow-transit constipation, the role of high-amplitude propagated contractions and loss of interstitial cells of Cajal in constipation, the role of serotonin in the gut, and the serotoninergic disturbances in IBS.

UR - http://www.scopus.com/inward/record.url?scp=33645569958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645569958&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33645569958

VL - 6

JO - Advanced Studies in Medicine

JF - Advanced Studies in Medicine

SN - 1530-3004

IS - 2 A

ER -